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ProteomicsIdentification of TMEM106B-binding proteins in mouse brain
TMEM106B is an endolysosomal transmembrane protein associated with many brain disorders, such as frontotemporal lobar degeneration, Alzheimer’s disease, and hypomyelinating leukodystrophy. In addition, recent cryo-EM studies have identified amyloid fibrils of carboxyl-terminal TMEM106B in the brains...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-06 | PXD043192 | Pride
Mouse Brain Lysosome Lc-ms/ms 
UnknownA gonococcal homologue of meningococcal gamma-glutamyl transpeptidase gene is a new type of bacterial pseudogene that is transcriptionally active but phenotypically silent.

Background

It has been speculated that the gamma-glutamyl transpeptidase (ggt) gene is present only in Neisseria meningitidis and not among related species such as Neisseria gonorrhoeae and Neisseria lactamica, because N. meningitidis is the only bacterium with GGT activity. However, nucleot...
S-EPMC1262726 | biostudies-literature
UnknownMeningococcal internalization into human endothelial and epithelial cells is triggered by the influx of extracellular L-glutamate via GltT L-glutamate ABC transporter in Neisseria meningitidis.
Meningococcal internalization into human cells is likely to be a consequence of meningococcal adhesion to human epithelial and endothelial cells. Here, we identified three transposon mutants of Neisseria meningitidis that were primarily defective in the internalization of human brain microvascular e...
S-EPMC3019876 | biostudies-literature
UnknownThe Meningococcal Cysteine Transport System Plays a Crucial Role in Neisseria meningitidis Survival in Human Brain Microvascular Endothelial Cells.
While Neisseria meningitidis typically exists in an asymptomatic nasopharyngeal carriage state, it may cause potentially lethal diseases in humans, such as septicemia or meningitis, by invading deeper sites in the body. Since the nutrient compositions of human cells are not always conducive t...
S-EPMC6299482 | biostudies-literature
UnknownMeningococcal PilV potentiates Neisseria meningitidis type IV pilus-mediated internalization into human endothelial and epithelial cells.
The type IV pilus of Neisseria meningitidis is the major factor for meningococcal adhesion to host cells. In this study, we showed that a mutant of N. meningitidis pilV, a minor pilin protein, internalized less efficiently to human endothelial and epithelial cells than the wild-type strain. Matrix-a...
S-EPMC3497409 | biostudies-literature
TranscriptomicsDe novo Assembly and Characterization of Swertia japonica Transcriptome for the Identification of Candidate Genes Involved in the Biosynthesis of Therapeutic Metabolites
Here, we performed deep transcriptome sequencing for the aerial-tissues and the roots of S. japonica, generating over 2 billion raw reads with an average length of 101 nt by using an Illumina paired-end sequencing by HiSeq2000 platform. Using a combined approach of three popular assemblers, de novo ...
ORGANISM(S): Swertia japonica 
2016-07-01 | E-GEOD-80057 | biostudies-arrayexpress
ProteomicsMS analysis of phosphopeptides enriched from the lumbar spinal cord of SOD1G93A mice at 20weeks.
This project is "Phosphoproteomic analysis of the lumbar spinal cord, a lesion site in the amyotrophic lateral sclerosis (ALS) mouse model SOD1G93A mice". The aim of this study is to clarify the phosphorylation changes by the lumbar spinal cord of SOD1G93A mice at 20w by applying proteomics technolo...
ORGANISM(S): Mus Musculus (mouse) 
PXD030651 | JPOST Repository
UnknownCommunity-Level Compact City Design, Health Care Provision, and Outcomes of Patients With Stroke.

Background

The optimal scale of urbanization for stroke health care provision and the potential impact of compact city design on stroke outcomes remain unclear. We investigated the impact of zip code area-level compact city design using the walkability index (WI) and its mediators on stroke ...
S-EPMC12449981 | biostudies-literature
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