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GenomicsOverexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer
Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-48308 | biostudies-arrayexpress
UnknownDenosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial.

Background

Bone metastases are a major cause of morbidity and mortality in men with prostate cancer. Preclinical studies suggest that osteoclast inhibition might prevent bone metastases. We assessed denosumab, a fully human anti-RANKL monoclonal antibody, for prevention of bone metastasis or...
S-EPMC3671878 | biostudies-literature
TranscriptomicsHPCX1 linked prostate cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-24205 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human prostate cancer cell lines, xenografts and tumor samples
miRNA expression profiling in 6 prostate cancer cell lines, 9 prostate cancer xenografts, and 13 clinical prostate tumor samples
ORGANISM(S): Homo sapiens 
2007-08-03 | E-MEXP-1058 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of human prostate cancer cell lines treated with 5azadC and TSA to investigate epigenetic modifications
miRNA expression profiling of prostate cancer cell lines, PC-3, DU145, LAPC-4, VCaP, LNCaP, 22rv1, and normal prostate epithelial cells, PrECs, was done after treating the cells with DNA demethylating agent 5-aza-2'-deoxycytidine (5azadC; Sigma-Aldrich, St. Louis, MO) and histone deacetylase inhibit...
ORGANISM(S): Homo sapiens 
2010-01-29 | E-MEXP-2313 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human prostate cancer
miRNA expression profiling of 13 clinical prostate samples, 4 benign prostate hyperplasias, 5 untreated primary prostate carcinomas and 4 castration-resistant prostate cancers.
ORGANISM(S): Homo sapiens 
2010-01-31 | E-MEXP-2319 | biostudies-arrayexpress
UnknownContribution of ARLTS1 Cys148Arg (T442C) variant with prostate cancer risk and ARLTS1 function in prostate cancer cells.
ARLTS1 is a recently characterized tumor suppressor gene at 13q14.3, a region frequently deleted in both sporadic and hereditary prostate cancer (PCa). ARLTS1 variants, especially Cys148Arg (T442C), increase susceptibility to different cancers, including PCa. In this study the role of Cys148Arg subs...
S-EPMC3197657 | biostudies-literature
UnknownMicroseminoprotein-Beta Expression in Different Stages of Prostate Cancer.
Microseminoprotein-beta (MSMB, MSMB) is an abundant secretory protein contributed by the prostate, and is implicated as a prostate cancer (PC) biomarker based on observations of its lower expression in cancerous cells compared with benign prostate epithelium. However, as the current literature on MS...
S-EPMC4777373 | biostudies-literature
UnknownA Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer.

Unlabelled

Prostate cancer is the second most common malignancy among men worldwide. Genome-wide association studies have identified 100 risk variants for prostate cancer, which can explain approximately 33% of the familial risk of the disease. We hypothesized that a comprehensive analysis o...
S-EPMC4390388 | biostudies-literature
UnknownRecurrent SKIL-activating rearrangements in ETS-negative prostate cancer.
Prostate cancer is the third most common cause of male cancer death in developed countries, and one of the most comprehensively characterized human cancers. Roughly 60% of prostate cancers harbor gene fusions that juxtapose ETS-family transcription factors with androgen regulated promoters. A second...
S-EPMC4467434 | biostudies-literature
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