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In this study, we conducted a comprehensive multi-omics analysis, including proteomics, transcriptomics, and ubiquitinomics, to investigate the mechanism of PF-3758309 in HCT116 cells. Our results revealed that PF-3758309 promotes the degradation of RNA polymerase II subunit proteins (POLR2A/B/E) vi...
ORGANISM(S): Homo Sapiens 
2025-06-05 | PXD064705 |
[original title] Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma. Background : Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma are two distinct but closely related entities with strong morphologic and geneti...
ORGANISM(S): Homo sapiens 
The hallmark of human cancer is heterogeneity, mirroring the complexity of genetic and epigenetic alterations acquired during oncogenesis. We extracted RNA of 34 cultured human ovarian carcinoma cell lines and performed expression microarrays so that cultured cell lines can represent in vivo human ...
ORGANISM(S): Homo sapiens 
The hallmark of human cancer is heterogeneity, mirroring the complexity of genetic and epigenetic alterations acquired during oncogenesis. We extracted DNA of 14 cultured human ovarian carcinoma cell lines subjected to pooled shRNA screen using TRC 1.0 library, and performed DNAseq. 14 ovarian carc...
ORGANISM(S): Homo sapiens 
Sepsis is often a cause of mortality in patients admitted to the intensive care unit. Notably, the heart is the organ most susceptible to the impact of sepsis.Mice injected intraperitoneally with LPS solution (20 mg/kg) were designated as the sepsis experimental group, while those injected intraperi...
ORGANISM(S): Mus Musculus 
2024-12-24 | PXD059227 |
Sepsis is often a cause of mortality in patients admitted to the intensive care unit. Notably, the heart is the organ most susceptible to the impact of sepsis.Mice injected intraperitoneally with LPS solution (20 mg/kg) were designated as the sepsis experimental group, while those injected intraperi...
ORGANISM(S): Mus Musculus 
2025-01-07 | PXD059523 |
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