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ProteomicsIntegrative proteomics and phosphoproteomics profiling and systems biology analysis reveal dynamic signaling networks and mTORC1-dependent mitochondrial function in T cell activation
The underlying mechanisms by which naïve T cells exit from quiescence after antigen stimulation remain elusive. Using multiplex isobaric labeling proteomics technology, we report unbiased, temporal profiling of whole proteome and phosphoproteome during the activation in the wild type and Rptor-/- T ...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-29 | PXD005492 | Pride
System biology T cell activation Mtorc1 Mass spectrometry Rptor Proteomic Phosphoproteomics Mitochondrial function 
ProteomicsIntegrative proteomics and phosphoproteomics profiling and systems biology analysis reveal dynamic signaling networks and mTORC1-dependent mitochondrial function in T cell activation
The underlying mechanisms by which naïve T cells exit from quiescence after antigen stimulation remain elusive. Using multiplex isobaric labeling proteomics technology, we report unbiased, temporal profiling of whole proteome (>8,000 proteins) and phosphoproteome (>13,000 phosphopeptides) during the...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-15 | PXD004367 | Pride
System biology T cell activation Mtorc1 Mass spectrometry Rptor Proteomic Phosphoproteomics Mitochondrial function 
UnknownComparison of the Effect of Vessel Size Imaging and Cerebral Blood Volume Derived from Perfusion MR Imaging on Glioma Grading.
Not available
S-EPMC7960212 | biostudies-literature
UnknownThe FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, Bombyx mori.
Not available
S-EPMC5512063 | biostudies-literature
UnknownIntegrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation.
Not available
S-EPMC5466820 | biostudies-literature
TranscriptomicsGEMINI (Gastric Encyclopedia of Molecular Interactions and Nodes for Intervention) Phases A-C
Genome-wide mRNA expression profiles of 25 unique gastric cancer cell lines (GCCLs). Gastric cancer (GC) is the second leading cause of global cancer mortality, with individual gastric tumors displaying significant heterogeneity in their deregulation of various oncogenic pathways. We aim to identify...
ORGANISM(S): Homo sapiens 
2009-10-06 | E-GEOD-15455 | biostudies-arrayexpress
TranscriptomicsGEMINI (Gastric Encyclopedia of Molecular Interactions and Nodes for Intervention) Phases A-C, normal skin fibroblasts
Genome-wide mRNA expression profiles of normal skin fibroblasts, used as one of the (normal) references in the study. Gastric cancer (GC) is the second leading cause of global cancer mortality, with individual gastric tumors displaying significant heterogeneity in their deregulation of various oncog...
ORGANISM(S): Homo sapiens 
2009-10-06 | E-GEOD-15537 | biostudies-arrayexpress
UnknownWWC1 genotype modulates age-related decline in episodic memory function across the adult life span.
Not available
S-EPMC3989426 | biostudies-literature
TranscriptomicsGastric Cancer Subtyping (Australian Patient Cohort)
Genome-wide mRNA expression profiles of 70 primary gastric tumors from the Australian patient cohort. Like many cancers, gastric adenocarcinomas (gastric cancers) show considerable heterogeneity between patients. Thus, there is intense interest in using gene expression profiles to discover subtypes ...
ORGANISM(S): Homo sapiens 
2012-07-04 | E-GEOD-35809 | biostudies-arrayexpress
UnknownEfficient mRNA delivery to resting T cells to reverse HIV latency.
Not available
S-EPMC12122926 | biostudies-literature
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