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MetabolomicsComputational mass spectrometry accelerates C=C position-resolved untargeted lipidomics using oxygen attachment dissociation
Mass spectrometry-based untargeted lipidomics has revealed the lipidome atlas of living organisms at the molecular species level. Despite the double bond (C=C) position being a crucial factor for enzyme preference, cellular membrane milieu, and biological activity, the C=C defined structures have no...
2022-11-09 | MTBLS5861 | MetaboLights
ProteomicsAD and FTLD model mouse, brain, Phosphoproteome
Using a high-end mass spectrometry, we screened phosphoproteins and phosphopeptides in five types of Alzheimer's disease (AD) mouse models (5xFAD, APP-tg, PS1-tg, PS2-tg and APP-KI) and four types of frontotemporal lobar degeneration (FTLD) mouse models(CHMP2B-KI, PGRN-KI, VCP-KI and TDP43-KI) at m...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-07 | PXD027119 | Pride
Ftld Ad Ftd Mouse Phosphoproteome 
ProteomicsHMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology
DNA damage is increased in Alzheimer’s disease (AD), while the underlying mechanisms are unknown. Here, we employ comprehensive phosphoproteome analysis, and identify abnormal phosphorylation of 70 kDa subunit of Ku antigen (Ku70) at Ser77/78, which prevents Ku70-DNA interaction, in human AD postmor...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028089 | Pride
Hmgb1 Ku70 Phosphorylation Alzheimer's disease 
TranscriptomicsPrognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer [gene expression]
Introduction: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Experimental design: The expression profiles of cancer cells ...
ORGANISM(S): Homo sapiens 
2015-11-21 | E-GEOD-64256 | biostudies-arrayexpress
TranscriptomicsPrognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer [copy number analysis]
Introduction: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Experimental design: The expression profiles of cancer cells ...
ORGANISM(S): Homo sapiens 
2015-11-21 | E-GEOD-64257 | biostudies-arrayexpress
TranscriptomicsInterferon signaling related gene expression and clinical outcome of chronic hepatitis C
Chronic hepatitis C (CH) frequently developed liver cirrhosis and hepatocellular carcinoma without suitable treatment. However, peginterferon(IFN) and ribavirin therapy (combination therapy), which is present standard therapy, is imperfect effect because of several side effect. We attempt to catalog...
ORGANISM(S): Homo sapiens 
2010-02-10 | E-GEOD-20119 | biostudies-arrayexpress
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