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ModelsMizuno2012 - AlzPathway: a comprehensive map of Alzheimer's disease
Mizuno2012 - AlzPathway: a comprehensive map of Alzheimer's disease Non-kinetic molecular map. Pure SBML file of AlzPathway provided by the authors as Additional file 5. This model is described in the article: AlzPathway: a comprehensive map of signaling pathways of Alzheime...
2016-05-09 | MODEL1504290001 | BioModels
Proteomics,MultiomicsComplementary critical functions of Zfy1 and Zfy2 in mouse spermatogenesis and reproduction
The mammalian Y chromosome plays a critical role in spermatogenesis. However, the exact functions of each gene in the Y chromosome have not been completely elucidated, partly owing to difficulties in gene targeting analysis of the Y chromosome. Zfy was first proposed to be a sex determination factor...
ORGANISM(S): Mus <mouse, Genus> (ncbitaxon:10088) 
2016-11-24 | MSV000080355 | MassIVE
TranscriptomicsPARVB overexpression increases migration capability and defines high risks for endophytic growth and metastasis in tongue squamous cell carcinoma.
Tongue squamous cell carcinoma (TSCC) varies in characteristics even in early stages and is mainly classified into three subtypes, which are superficial, exophytic and endophytic types, based on a macroscopic appearance of tumor growth.Of these subtypes, endophytic tumor has a poorer prognosis becau...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-52915 | biostudies-arrayexpress
TranscriptomicsSynergistic Tumor Suppressor Activity of E-cadherin and p53 in a Conditional Mouse Model for Diffuse-Type Gastric Cancer
BACKGROUND & AIMS: Gastric cancer is the second most frequent cause of death from cancer in the world, diffuse-type gastric cancer (DGC) exhibiting a poor prognosis. Germline mutations of CDH1, encoding E-cadherin, have been reported in hereditary DGCs, and genetic and/or epigenetic alterations of C...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-25302 | biostudies-arrayexpress
MetabolomicsComputational mass spectrometry accelerates C=C position-resolved untargeted lipidomics using oxygen attachment dissociation
Mass spectrometry-based untargeted lipidomics has revealed the lipidome atlas of living organisms at the molecular species level. Despite the double bond (C=C) position being a crucial factor for enzyme preference, cellular membrane milieu, and biological activity, the C=C defined structures have no...
2022-11-09 | MTBLS5861 | MetaboLights
TranscriptomicsTranscription profiling of S. cerevisiae T128 was used as a model of typical commercial bakers yeast used in Japan to investigation of stress responses during commercial fermentation
Gene expression profiles of baker’s yeast during initial dough-fermentation were investigated using liquid fermentation media to obtain insights at the molecular level into rapid adaptation mechanisms of baker’s yeast. Results showed that onset of fermentation caused drastic changes in gene expr...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3043 | biostudies-arrayexpress
TranscriptomicsGene expression data from the LEC rat model with naturally occuring and oxidative stress induced liver tumorigenesis
To elucidate the fundamental molecular mechanisms responsible for multistep hepatotumorigenesis, this study investigated genes that were upregulated in a stepwise manner from the naïve liver condition through to chronic oxidative stress-induced hepatitis and liver tumor by time-series microarray ana...
ORGANISM(S): Rattus norvegicus 
2009-07-30 | E-GEOD-17384 | biostudies-arrayexpress
TranscriptomicsMicroarray-based global mapping of integration sites of retrotransposon, intracisternal A-particle, in mouse genome
Mammalian genomes have evolutionary harbored numerous mobile elements, a part of which are still active and evoke genomic instability. Their movement and positional diversity occasionally result in phenotypic changes and variation by causing altered expression and disruption of neighboring genes in...
ORGANISM(S): Mus musculus 
2008-05-03 | E-GEOD-9572 | biostudies-arrayexpress
TranscriptomicsClinical Significance of Osteoprotegerin Expression in Human Colorectal Cancer
Purpose: This study aimed to identify a novel biomarker or a target of treatment for colorectal cancer (CRC). Experimental Design: The expression profiles of cancer cells in 104 patients with CRC were examined using laser microdissection and oligonucleotide microarray analysis. Overexpression in CRC...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-21510 | biostudies-arrayexpress
TranscriptomicsOverexpression of NUCKS1 in colorectal cancer correlates with recurrence after curative surgery (copy number analysis)
Purpose: The purpose of this study is to identify a novel biomarker related with distant metastases of colorectal cancer (CRC). Experimental Design: We investigated mRNA expression profiles in 115 patients with CRC using an Affymetrix Gene Chip, and copy number profiles in 122 patients with CRC usin...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-27910 | biostudies-arrayexpress
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