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TranscriptomicsGene expression data from the LEC rat model with naturally occuring and oxidative stress induced liver tumorigenesis
To elucidate the fundamental molecular mechanisms responsible for multistep hepatotumorigenesis, this study investigated genes that were upregulated in a stepwise manner from the naïve liver condition through to chronic oxidative stress-induced hepatitis and liver tumor by time-series microarray ana...
ORGANISM(S): Rattus norvegicus 
2009-07-30 | E-GEOD-17384 | biostudies-arrayexpress
TranscriptomicsPrognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-11-21 | E-GEOD-64258 | biostudies-arrayexpress
TranscriptomicsSynergistic Tumor Suppressor Activity of E-cadherin and p53 in a Conditional Mouse Model for Diffuse-Type Gastric Cancer
BACKGROUND & AIMS: Gastric cancer is the second most frequent cause of death from cancer in the world, diffuse-type gastric cancer (DGC) exhibiting a poor prognosis. Germline mutations of CDH1, encoding E-cadherin, have been reported in hereditary DGCs, and genetic and/or epigenetic alterations of C...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-25302 | biostudies-arrayexpress
TranscriptomicsOverexpression of NUCKS1 in colorectal cancer correlates with recurrence after curative surgery
This SuperSeries is composed of the following subset Series: GSE27854: Overexpression of NUCKS1 in colorectal cancer correlates with recurrence after curative surgery (gene expression analysis) GSE27910: Overexpression of NUCKS1 in colorectal cancer correlates with recurrence after curative surgery ...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-27913 | biostudies-arrayexpress
TranscriptomicsMepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease
For the clinical treatment of chronic obstructive pulmonary disease (COPD), it is important not only to improve the airflow limitation by bronchodilation but also to suppress emphysema by controlling inflammation. In this study, we have screened for compounds that prevent elastase-induced airspace ...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-50836 | biostudies-arrayexpress
TranscriptomicsGene expression changes in initiation and progression of oral squamous cell carcinomas revealed by laser microdissection and oligonucleotide microarray analysis
Background. Oral carcinogenesis is a complex process involving multiple genes. However, the genetic changes involved in this process are not demonstrated in the identical oral squamous carcinomas (OSCCs). Methods. According to the pathological characteristics, parts of normal tissues, oral dysplasti...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-35261 | biostudies-arrayexpress
TranscriptomicsIntrahepatic miRNA/mRNA expression in non-responders to pegylated interferon plus ribavirin combination therapy for chronic hepatitis C (miRNA microarray data)
Despite advance in interferon-based treatment for chronic hepatitis C, difficult-to-treat patients remain in existence yet. To identify key genes involved in difficult-to-treat characteristics, gene expression patterns of miRNA and RNA were analyzed by profiling pretreatment liver tissues from five ...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-45179 | biostudies-arrayexpress
TranscriptomicsIntrahepatic miRNA/mRNA expression in non-responders to pegylated interferon plus ribavirin combination therapy for chronic hepatitis C
Despite advance in interferon-based treatment for chronic hepatitis C, difficult-to-treat patients remain in existence yet. To identify key genes involved in difficult-to-treat characteristics, gene expression patterns of miRNA and RNA were analyzed by profiling pretreatment liver tissues from five ...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-42697 | biostudies-arrayexpress
TranscriptomicsClinical Significance of Osteoprotegerin Expression in Human Colorectal Cancer
Purpose: This study aimed to identify a novel biomarker or a target of treatment for colorectal cancer (CRC). Experimental Design: The expression profiles of cancer cells in 104 patients with CRC were examined using laser microdissection and oligonucleotide microarray analysis. Overexpression in CRC...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-21510 | biostudies-arrayexpress
TranscriptomicsOverexpression of NUCKS1 in colorectal cancer correlates with recurrence after curative surgery (copy number analysis)
Purpose: The purpose of this study is to identify a novel biomarker related with distant metastases of colorectal cancer (CRC). Experimental Design: We investigated mRNA expression profiles in 115 patients with CRC using an Affymetrix Gene Chip, and copy number profiles in 122 patients with CRC usin...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-27910 | biostudies-arrayexpress
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