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MetabolomicsXiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights
MetabolomicsTracer-based Metabolomics Technology to Investigate the Role and Mechanism of Fangji Huangqi Tang in Regulating Lipid Metabolism Disorders in MPC-5 Cells
Lipid metabolism disorders play a critical role in the progression of nephrotic syndrome (NS). Although the traditional Chinese medicine formula Fangji Huangqi Tang (FHT) has been shown to restore lipid homeostasis in vivo, its specific molecular targets and effects on dynamic lipid metabolism in po...
2026-09-20 | MTBLS14277 | MetaboLights
TranscriptomicsThe Fun30 ATP-dependent nucleosome remodeler promotes resection of DNA double-strand break ends
Chromosomal double-strand breaks (DSBs) are resected by 5M-bM-^@M-^Y-nucleases to form 3M-bM-^@M-^Y single-strand DNA (ssDNA) substrates for binding by homologous recombination and DNA damage checkpoint proteins. Two redundant pathways of extensive resection were described both in cells and in vitro...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-04 | E-GEOD-38601 | biostudies-arrayexpress
UnknownMontelukast and Telmisartan as Inhibitors of SARS-CoV-2 Omicron Variant.
Not available
S-EPMC10385313 | biostudies-literature
TranscriptomicsTranscription profiling of hairy roots of M. trunculata transformed with TT2
M. truncatula was transformed with TT2 (transparent testa2 from Arabidopsis) using Agrobacterium rhizogene and the transgenic hairy roots were used for gene profiling in comparison with empty vector control.
ORGANISM(S): Medicago truncatula 
2008-11-26 | E-MEXP-1115 | biostudies-arrayexpress
MetabolomicsMulti-country metabolic signature discovery for chicken health classification

INTRODUCTION: To decrease antibiotic resistance, their use as growth promoters in the agricultural sector has been largely abandoned. This may lead to decreased health due to infectious disease or microbiome changes leading to gut inflammation.

OBJECTIVES: ...

2023-08-08 | MTBLS5065 | MetaboLights
TranscriptomicsTracing pluripotency of human early embryos and embryonic stem cells by single cell RNA-seq
Find the casual relationship between gene expression network and cellular phenotype at single cell resolution. We collected donated human pre-implatation embryos, and the embryonic stem cells derived from them, isolate individual cells, prepared single cell cDNAs, and sequenced them by HiSeq2000. Th...
ORGANISM(S): Homo sapiens 
2013-08-10 | E-GEOD-36552 | biostudies-arrayexpress
UnknownSalt tolerance evaluation and mini-core collection development in Miscanthus sacchariflorus and M. lutarioriparius.
Not available
S-EPMC10948507 | biostudies-literature
UnknownUrinary PGE-M in Men with Prostate Cancer.
Not available
S-EPMC8391815 | biostudies-literature
ProteomicsThe ribonuclease DISL-2 mediates piRNA degradation
The PIWI/piRNA pathway acts as a conserved RNA-directed immune mechanism that suppresses transposons and promotes fertility. The biogenesis of piRNAs has been extensively investigated since their discovery, yet the mechanisms governing piRNA degradation remain poorly understood. Here, we systematica...
ORGANISM(S): Caenorhabditis elegans 
2025-09-07 | PXD060979 | Pride
Pirna degradation Ribonuclease Piwi 
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