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MetabolomicsGluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and H3K9me3 to suppress HCC progression
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic enzyme PCK1 fuels the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransfera...
2025-08-09 | MTBLS7651 | MetaboLights
ProteomicsS-nitrosoproteome of pancreatic ductal adenocarcinoma
NO performs its biological roles mainly through protein S-nitrosylation, but pathogenic roles of protein S-nitrosylation in PDAC remains largely unexplored. In this study, we identified large number of unique S-nitrosylation sites and proteins in PDAC patients and PANC-1 cells by a site-specific pro...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012512 | Pride
Pancreatic ductal adenocarcinoma Panc-1 S-nitrosoproteome 
TranscriptomicsGene expression profiles of MCF-7 cells treated with Si-Wu-Tang, estradiol and ferulic acid
Traditional Chinese medicines (TCM), usually composed of a mixture of components, may simultaneously target multiple genes/pathways and thus achieve superior efficacy for complex diseases such as cancer. To identify novel mechanisms of action and potential health benefits for a TCM formula Si-Wu-Tan...
ORGANISM(S): Homo sapiens 
2011-05-18 | E-GEOD-23610 | biostudies-arrayexpress
ProteomicsProteomic analysis of S-nitrosylation in HUVECs
HUVECs stimulated with HG+oxLDL or Mannitol+nLDL were subjected to the biotin-switch assay to enrich the S-nitrosylated proteins, the S-nitrosylated proteins were resolved by SDS-PAGE and gels were silver stained. Mass spectrometry was conducted to determine proteins with S-nitrosylation.
ORGANISM(S): Homo sapiens (Human) 
2021-06-03 | PXD025295 | Pride
S-nitrosylation Oxldl Mass spectrometry Huvecs Hg 
ProteomicsMechanisms research on Huangqin Tang interference with colitis associated colorectal cancer
Although the exact molecular mechanisms of colitis associated col orectal cancer are not fully understood, the chronic inflammation positively correlated with tumorigenesis. The Traditional Chinese Medicine botanical formulation Huangqin Tang has significant anti-inflammatory effects. We investigate...
ORGANISM(S): Mus Musculus 
2022-02-16 | PXD031696 |
ProteomicsS-palmitoylation of MAP kinase is essential for fungal virulence
acylation also called S-palmitoylation is an important reversible protein post-translational modification in organisms. However, its function remains unknown in pathogenic fungi. Here, we found treatment of rice false fungus Ustilaginoidea virens with S-palmitoylation inhibitor 2-BP resulted in a si...
ORGANISM(S): Ustilaginoidea virens 
2024-10-14 | PXD048216 | Pride
S-palmitoylation  biotin  ustilaginoidea virens  virulence 
UnknownInteraction between Porcine Alveolar Macrophage-Tang Cells and Streptococcus suis Strains of Different Virulence: Phagocytosis and Apoptosis.
Not available
S-EPMC9863715 | biostudies-literature
UnknownHigh performance C/S composite cathodes with conventional carbonate-based electrolytes in Li-S battery.
Not available
S-EPMC4003480 | biostudies-literature
UnknownProtective Activities of Dendrobium huoshanense C. Z. Tang et S. J. Cheng Polysaccharide against High-Cholesterol Diet-Induced Atherosclerosis in Zebrafish.
Not available
S-EPMC7366212 | biostudies-literature
UnknownPERMANOVA-S: association test for microbial community composition that accommodates confounders and multiple distances.
Not available
S-EPMC5013911 | biostudies-literature
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