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UnknownAlkaline phosphatase-to-albumin ratio as a novel predictor of long-term adverse outcomes in coronary artery disease patients who underwent PCI.
Alkaline phosphatase (ALP) and albumin (ALB) have been shown to be associated with coronary artery disease (CAD), and it has been reported that alkaline phosphatase-to-albumin ratio (AAR) is associated with the liver damage and poorer prognosis of patients with digestive system malignancy. Moreover,...
S-EPMC8243337 | biostudies-literature
ProteomicsSTXBP5 prevents reannealing of autophagic cis-SNARE disassembled by NSF/αSNAP
We generated a HEK293 cell line expressing ZZ-TEV-FLAG-bait protein by Lipofectamine 3000 transfection. The expression level of bait protein is controlled to endogenous level by addition of 2 ng/mL doxycycline. Note the combined treatment of Torin1 and CQ was applied for STX17. The tandem affinity p...
ORGANISM(S): Homo sapiens (Human) 
2023-09-18 | PXD043048 | Pride
Stxbp5 Alphasnap Autophagy Disassemble Snare Nsf 
UnknownDevelopmental control of CaV1.2 L-type calcium channel splicing by Fox proteins.
CaV1.2 voltage-gated calcium channels play critical roles in the control of membrane excitability, gene expression, and muscle contraction. These channels show diverse functional properties generated by alternative splicing at multiple sites within the CaV1.2 pre-mRNA. The molecular mechanisms contr...
S-EPMC2725710 | biostudies-literature
UnknownIncorporation of quantum dots in silk biomaterials for fluorescence imaging.
Tracking the distribution and degradation of biomaterials after in vivo implantation or injection is important for tissue engineering and drug delivery. Intrinsic and externally labeled fluorescence has been widely used for these purposes. In the present study, 3-mercaptopropionic acid (MPA)-...
S-EPMC4527682 | biostudies-literature
UnknownEvaluation of toxoplasmosis in pregnant women using dot-immunogold-silver staining with recombinant Toxoplasma gondii peroxiredoxin protein.

Background

Toxoplasma gondii infection endangers human health and affects animal husbandry. Serological detection is the main method used for epidemiological investigations and diagnosis of toxoplasmosis. The key to effective diagnosis of toxoplasmosis is the use of a standardized antigen an...
S-EPMC7507715 | biostudies-literature
Unknownβ-Amyrin synthase from Conyza blinii expressed in Saccharomyces cerevisiae.
Conyza blinii H.Lév. is a widely used medicinal herb in southwestern China. The main pharmacological components of C. blinii are a class of oleanane-type pentacyclic triterpene glycosides known as conyzasaponins, which are thought to be synthesized from β-amyrin. However, no genes invo...
S-EPMC5623702 | biostudies-literature
UnknownA high-throughput neutralizing assay for antibodies and sera against hepatitis E virus.
Hepatitis E virus (HEV) is the aetiological agent of enterically transmitted hepatitis. The traditional methods for evaluating neutralizing antibody titres against HEV are real-time PCR and the immunofluorescence foci assay (IFA), which are poorly repeatable and operationally complicated, factors th...
S-EPMC4848499 | biostudies-literature
UnknownA Comprehensive Study of Neutralizing Antigenic Sites on the Hepatitis E Virus (HEV) Capsid by Constructing, Clustering, and Characterizing a Tool Box.
The hepatitis E virus (HEV) ORF2 encodes a single structural capsid protein. The E2s domain (amino acids 459-606) of the capsid protein has been identified as the major immune target. All identified neutralizing epitopes are located on this domain; however, a comprehensive characterization of antige...
S-EPMC4528150 | biostudies-literature
UnknownA small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors.
Residual disease is the major cause for colorectal cancer (CRC) relapse. Herein, we explore whether and how a natural molecule CADPE killed heterogenic populations in a panel of CRC cell lines with KRAS/BRAF mutations that are natively resistant to EGFR- or VEGFR-targeted therapy, without sparing pe...
S-EPMC7667164 | biostudies-literature
UnknownThe long-term spatio-temporal trends in burden and attributable risk factors of major depressive disorder at global, regional and national levels during 1990-2019: a systematic analysis for GBD 2019.

Aims

Caused by multiple risk factors, heavy burden of major depressive disorder (MDD) poses serious challenges to public health worldwide over the past 30 years. Yet the burden and attributable risk factors of MDD were not systematically known. We aimed to reveal the long-term spatio-tempora...
S-EPMC11362682 | biostudies-literature
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