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TranscriptomicsReal-time quantitative PCR analysis of DZNep treated B cell Lymphoma cell line Jeko-1
Jeko-1 cells were culture with or without PRC2 inhibitor 3-deazaneplanocin A (DZNep)(1uM) for 72hrs. We used TaqManM-BM-. Human MicroRNA Array to quantitate miRNA expression profile regulated by PRC2. qPCR miRNA expression profiling.
ORGANISM(S): Homo sapiens 
2012-08-11 | E-GEOD-40019 | biostudies-arrayexpress
TranscriptomicsSUDHL-4 cells: suspension vs. co-cultured with HK cells
We first performed miRNA analysis on SU-4 cells in suspension, and after 24 and 48 h of HK co-culture. To ensure that no HK cell contamination occurred, SU-4 cells in suspension and after co-culture were purified by CD19-positive magnetic selection, followed by total RNA isolation. Two-condition exp...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-49253 | biostudies-arrayexpress
ProteomicsABPP of Ibrutinib Resistance in B Cell Malignancies
Ibrutinib,a novel Bruton'styrosine kinase inhibitor, demonstrated high response rates in B-cell lymphomas but a growing number of ibrutinib treated patients relapse with resistance, fulminant progression and accelerated mortality. Using chemical proteomics and a high-throughput ex vivo assay in a re...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005734 | Pride
Ibrutinib Activity-based protein profiling B-cell cancers Lc-ms/ms 
ProteomicsBCL2 amplicon loss and super-enhancer remodeling drives ABT-199 resistance
Drug-tolerant “persister” tumor cells underlie the emergence of drug-resistant clones contribute to relapse and disease progression; thus, identifying actionable targets that disable persisters and mitigate relapse are a high priority need. Although the BCL2-targeting agent venetoclax (ABT-199) has ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010193 | Pride
Abpp Lymphoma Persister Apoptosis 
Proteomicsyagwall_712rpt
enrichment for Halobacterium cell wall proteins; 700-1200 m/z; Goo et al., unpublished data.
ORGANISM(S): Halobacterium Nrc-1 (halobacterium) 
2006-12-31 | PAe000225 | PeptideAtlas
UnknownEvaluation of the therapeutic effects of QuickOpt optimization in Chinese patients with chronic heart failure treated by cardiac resynchronization.
In this trial, long-term therapeutic effects and clinical improvements in Chinese chronic heart failure patients optimized by QuickOpt or echocardiography were compared for atrioventricular (AV) and interventricular (VV) delay optimizations after cardiac resynchronization therapy (CRT) with pacing (...
S-EPMC5844885 | biostudies-literature
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