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TranscriptomicsDissecting the specific role of Oct4 during the early stage of reprogramming
Differentiated cells can be reprogrammed into induced pluripotent stem cells (iPSCs) following the forced overexpression of a specific combination of transcription factors, of which Oct4 is essential. To better understand the mechanism underlying iPSC reprogramming, we investigated the immediate tr...
ORGANISM(S): Mus musculus 
2014-05-13 | E-GEOD-47061 | biostudies-arrayexpress
TranscriptomicsReprogramming to pluripotency through a somatic stem cell intermediate
In the past years, transdifferentiation from one lineage to another has become an important research field. In that context, we recently reported the direct reprogramming of mouse embryonic fibroblasts (MEFs) into induced neural stem cells (iNSCs). In this study, we, for the first time, successfully...
ORGANISM(S): Mus musculus 
2014-03-28 | E-GEOD-44284 | biostudies-arrayexpress
TranscriptomicsDirect Reprogramming of Fibroblasts into Epiblast Stem Cells
Embryonic stem cells (ESCs), which are derived from the primitive ectoderm of pre-implantation blastocysts, are pluripotent cells and can thus contribute to the formation of all somatic cell lineages in chimeric animals. Similarly, epiblast stem cells (EpiSCs), which are derived from epiblast tissu...
ORGANISM(S): Mus musculus 
2010-12-08 | E-GEOD-21516 | biostudies-arrayexpress
TranscriptomicsDirect Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors
Recent advances in the stem cell biology have revealed that cell type-specific transcription factors could reset the somatic memory and induce direct reprogramming into specific cellular identities. The induction of pluripotency in terminally differentiated cells has been a major achievement in the ...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-30500 | biostudies-arrayexpress
TranscriptomicsEpiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages
Embryonic stem cells (ESCs) comprise at least two populations of cells with divergent states of pluripotency. Here, we show that epiblast stem cells (EpiSCs) also comprise two distinct cell populations that can be distinguished by the expression of a specific Oct4-GFP marker. These two subpopulation...
ORGANISM(S): Mus musculus 
2011-02-24 | E-GEOD-17984 | biostudies-arrayexpress
TranscriptomicsHuman adult germline stem cells in question
Conrad et al. Nature 456, 344–349 (2008) have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression ...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-17772 | biostudies-arrayexpress
TranscriptomicsInduction of Pluripotency in Adult Unipotent Germline Stem Cells
Mouse and human stem cells with features similar to those of embryonic stem cells have been derived from testicular cells. Although pluripotent stem cells have been obtained from defined germline stem cells (GSCs) of mouse neonatal testis, only multipotent stem cells have been obtained so far from d...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-16178 | biostudies-arrayexpress
TranscriptomicsDifferent reprogramming methods generate undistinguishable pluripotent states
Pluripotency can be induced from different cell types using different methods. Several studies have reported that iPSC retain an epigenetic memory from the tissue from which they were derived. However, the influence of the method used for reprogramming in the final pluripotent state has not been inv...
ORGANISM(S): Mus musculus 
2015-12-17 | E-GEOD-42993 | biostudies-arrayexpress
TranscriptomicsGeneration of Induced Pluripotent Stem Cells from Human Testis Biopsy Derived Fibroblastic Cells
Although reported more than once, the generation of pluripotent stem cell populations from human testis remains questionable. We recently showed that the so - called human adult germline stem cells (haGSCs), which were claimed to be pluripotent, showed a gene expression profile comparable to human f...
ORGANISM(S): Homo sapiens 
2011-04-02 | E-GEOD-21179 | biostudies-arrayexpress
TranscriptomicsNanog-induced intestinal and colonic hyperplasia
Though expression of the homeobox transcription factor Nanog is generally restricted to pluripotent cells and early germ cells, recent reports have found that Nanog is re-expressed in somatic and germ cell tumors associated with poor differentiation and aggressive disease progression. To elucidate ...
ORGANISM(S): Mus musculus 
2014-08-11 | E-GEOD-31413 | biostudies-arrayexpress
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