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MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target
Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell biology ...
2026-04-24 | MTBLS14357 | MetaboLights
MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target

Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell ...

2026-03-13 | MTBLS13992 | MetaboLights
ProteomicsIntact HepG2 CHKA target engagement with CETSA
To confirm UNC638 and UNC737 target engagement to CHKA in live cells.
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD057925 | Pride
Cetsa Human Chka 
TranscriptomicsThe RDE-10/RDE-11 complex triggers RNAi induced mRNA degradation by association with target mRNA in C. elegans
The molecular mechanisms for target mRNA degradation in C. elegans undergoing RNA interference (RNAi) are not fully understood. Using a combination of genetic, proteomic and biochemical approaches, we report a divergent RDE-10/RDE-11 complex that is required for RNAi in C. elegans. The RDE-10/RDE-...
ORGANISM(S): Caenorhabditis elegans 
2012-04-25 | E-GEOD-36494 | biostudies-arrayexpress
ProteomicsAssessing target engagment using proteome-wide solvent shift assays
Recent advances in mass spectrometry (MS) have enabled quantitative proteomics to become a powerful tool in the field of drug discovery, especially when applied toward proteome-wide target engagement studies. Similar to temperature gradients, increasing concentrations of organic solvents stimulate u...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026297 | Pride
Target enagagement 
ProteomicsA BRET Biosensor for Measuring Uncompetitive Engagement of PRMT5 Complexes in Cells
Protein arginine methyl transferase 5 (PRMT5) plays a global role in cell physiology and is an established therapeutic target in cancer. In approximately 10-15% of human cancers, deletion of the methylthioadenosine phosphorylase (MTAP) gene results in accumulation of methylthioadenosine (MTA), expos...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD028138 | Pride
Nanobret - chemical proteomics – cell-based assay – sam – target engagement – thermal profiling 
ProteomicsA probe-based target engagement assay for kinases in live cells
Protein kinases are an important class of drug targets due to their crucial roles in almost every aspect of cellular function, such as cell growth, metabolism, proliferation, differentiation, migration, effector functions and cell death. Starting from the previously described covalent promiscuous ki...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD047949 | Pride
Cellular target engagement Jurkat cells Lc-ms/ms 
ProteomicsIdentification of PMV as the target of WEHI-601
Live cell DIA Thermal PISA profiling of WEHI-601 target engagement.
ORGANISM(S): Plasmodium (plasmodium) 
2026-02-14 | PXD069420 | JPOST Repository
ProteomicsChemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis via SYK activation
Identification of covalently bound protein targets of probe WEL028 in wild-type or mutant HL-60 cells.
ORGANISM(S): Homo sapiens (Human) 
2020-05-25 | PXD018270 | Pride
Target validation Chemical genetics Inhibitor Target engagement Chemical biology Kinase Probe 
ProteomicsA selective photoaffinity probe enables assessment of cannabinoid CB2 receptor expression and ligand engagement in human cells
Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression levels and receptor occupancy by small molecules are highly desirable. We report the development of LEI121 as a photoreactive probe to study the type 2 cannabinoid receptor (CB2R), a promising GPCR to treat tissue...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2018-06-15 | PXD008460 | Pride
Target engagement Cb2 receptor Gpcrs Photo-affinity labeling Bio-orthogonal chemistry 
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