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MetabolomicsThe patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain. All previously studied Omp85 proteins promote c...

2025-12-08 | MTBLS9803 | MetaboLights
TranscriptomicsChromatin immunoprecipitation of Bacillus subtilis to identify Noc protein binding sites
Coordination of chromosome segregation and cytokinesis is crucial for efficient cell proliferation. In Bacillus subtilis the nucleoid occlusion protein Noc protects chromosomes by associating with the chromosome and preventing cell division in its vicinity. Using protein localization, ChAP-on-Chip a...
ORGANISM(S): Bacillus subtilis 
2009-07-01 | E-MEXP-2133 | biostudies-arrayexpress
TranscriptomicsAMPK epidermal inhibition promotes HuR cytoplasmic localization eliciting post-transcriptional inflammatory response in psoriasis
IL-20 cytokines are involved in the establishment of psoriasis, a common chronic skin inflammation epidemiologically associated with metabolic syndrome, but molecular mechanisms underlying their over-expression remain to be elucidated. We find that keratinocytes (KCs) expressed IL-20 and lymphocytes...
ORGANISM(S): Homo sapiens 
2015-09-08 | E-GEOD-50598 | biostudies-arrayexpress
TranscriptomicsSensing Cardiac Electrical Activity with a Cardiomyocyte Targeted Optogenetic Voltage Indicator
Rationale: Monitoring and controlling cardiomyocyte activity with optogenetic tools offers exciting possibilities for fundamental and translational cardiovascular research. Genetically encoded voltage indicators may be particularly attractive for minimal invasive and repeated assessments of cardiac ...
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-69190 | biostudies-arrayexpress
UnknownEngineered protein nano-compartments for targeted enzyme localization.
Not available
S-EPMC3299773 | biostudies-literature
ProteomicsHybrid-DIA: Intelligent Data Acquisition for Simultaneous Targeted and Discovery Phosphoproteomics in Single Spheroids
Achieving sufficient coverage of regulatory phosphorylation sites by mass spectrometry (MS)-based phosphoproteomics for signaling pathway reconstitution is challenging when analyzing tiny sample amounts. We present a novel hybrid data-independent acquisition (DIA) strategy (hybrid-DIA) that combines...
ORGANISM(S): Homo sapiens (Human) 
2023-05-18 | PXD038947 | Pride
Phosphoproteomics Targeted Discovery Proteomics Spheroids 
ProteomicsDetermination of Phosphorylation Sites in the DivIVA Protein of Streptomyces coelicolor by Targeted LC-MS/MS
The filamentous bacterium Streptomyces coelicolor modulates polar growth and branching by phosphorylating the cytoskeletal protein DivIVA. Previous MALDI-TOF analysis of DivIVA showed that a large 7.2 kDa tryptic peptide was multiply phosphorylated. To aid localization of the phosphorylation sites, ...
ORGANISM(S): Streptomyces coelicolor 
2013-08-05 | PXD000095 | Pride
Phosphopeptides Targeted lc-ms/ms Phosphorylation site localization Diviva Orbitrap Scaffoldptm Ascore 
GenomicsGenome-wide mapping of early replication fragile sites (ERFS)
DNA double strand breaks (DSBs) in B lymphocytes are thought to arise stochastically during replication (S phase) or as a result of targeted DNA damage by activation induced cytidine deaminase (AID) in G1. Here we identify a novel class of recurrent, early replicating and AID independent DNA lesi...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-43504 | biostudies-arrayexpress
TranscriptomicsFunctional signature for the recognition of specific target mRNAs by human staufen1 protein
Cellular mRNAs are permanently associated to proteins in the form of ribonucleoprotein particles. In addition to the hnRNP and SR protein families, the double-stranded RNA-binding (DRB) proteins play important roles in mRNA synthesis, modification, activity and decay (Dreyfuss et al, 2002; Stutz & I...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-47226 | biostudies-arrayexpress
UnknownTargeted Protein Localization by Covalent 14-3-3 Recruitment.
Not available
S-EPMC12011284 | biostudies-literature
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