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UnknownSphingosine-1 Phosphate Receptor Modulators Increase In Vitro Melanoma Cell Line Proliferation at Therapeutic Doses Used in Patients with Multiple Sclerosis.
Not available
S-EPMC9837347 | biostudies-literature
UnknownCherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages.
Not available
S-EPMC4396483 | biostudies-literature
ProteomicsIdentification of deubiquitinases controlled by extracellular matrix stiffness in cancer cells
The project was aimed at identifying deubiquitinases (DUBs) involved in cancer cell mechanosignaling. Lysates from cancer cells grown on collagen matrices with varying stiffnesses were incubated with an activity-based HA-tagged ubiquitin probe that covalently binds DUB active site. To identify DUBs ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-22 | PXD054010 | Pride
Lc-ms/ms Immunopurification Dub abp Ecm stiffness 
ProteomicsTargeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy
To investigate the contribution of fibroblast-derived extracellular matrices (ECMs) to the resistance to targeted therapies in BRAF-mutated melanoma cells, we generated native-like 3D ECMs from human primary fibroblasts obtained from healthy individuals or melanoma patients. Cell-derived matrices fr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-12 | PXD026645 | Pride
Lc-msms Resistance Targeted therapies Melanoma Ddr Extracellular matrix 
UnknownTargeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma.
Not available
S-EPMC8819497 | biostudies-literature
UnknownThe mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential.
Not available
S-EPMC10074106 | biostudies-literature
UnknownBlockade of the pro-fibrotic reaction mediated by the miR-143/-145 cluster enhances the responses to targeted therapy in melanoma.
Not available
S-EPMC8899916 | biostudies-literature
UnknownComparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.
Not available
S-EPMC5451227 | biostudies-literature
UnknownA 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment.
Not available
S-EPMC8120228 | biostudies-literature
ProteomicsProteomic analysis of melanoma resistant cells transfected with siRNA targeting DDR2 or treated with DDR2 inhibitor or Dasatinib
Combined therapy with anti-BRAF plus anti-MEK is currently used as first-line treatment of patients with metastatic melanomas harboring the somatic BRAF V600E mutation. However, the main issue with targeted therapy is the acquisition of tumor cell resistance. In 70% of resistant melanoma cells, the ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-02 | PXD028292 | Pride
Resistance Quantitative proteome Melanoma Discoidin domain receptors 
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