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ModelsYuraszeck2010 - Vulnerabilities in the Tau Network in Tau Pathophysiology
Yuraszeck2010 - Vulnerabilities in the Tau Network in Tau Pathophysiology This model is described in the article: Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology. Yuraszeck TM, Neveu P, Rodriguez-Fernandez M, Robinson A, Kosik ...
2024-09-02 | BIOMD0000000542 | BioModels
ProteomicsPathogenic human tau in the Line 66 model of frontotemporal dementia
Transgenic human tau in subcellular fractions extracted after electrophoresis of L66 mouse brain extract. For higher sequence coverage trypsin (Tr) and thermolysin (TL) digests were analysed.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-08-13 | MSV000085945 | MassIVE
ProteomicsTruncated Tau
Tau is a microtubule-associated protein that ensures neuronal shape and function. Besides, Tau is a central player in Alzheimer’s disease (AD) and related Tauopathies where it is found aggregated in degenerating neurons. Mechanisms leading to Tau pathology and its progression are far from being eluc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-27 | MSV000081020 | MassIVE
ProteomicsProperties of Alzheimer’s disease brain-derived tau aggregates define tau processing by human astrocytes
The templated misfolding of tau proteins accounts for tau pathology spread in Alzheimer’s disease (AD). Post-translational modifications, including phosphorylation at specific residues, are closely linked with tau seeding ability and clinical disease progression. This study investigates the role of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056614 | Pride
Tau  alzheimer’s disease  astrocyte 
ProteomicsAnalysis of pathological tau associated with a wide range of tauopathies
We have analyzed and compared the post-translational modifications in the pathological tau proteins prepared from a wide range of tauopathies.
ORGANISM(S): Homo Sapiens (human) 
2020-07-15 | PXD020371 | JPOST Repository
ProteomicsPhysiological tau interactome in brain and its link to tauopathies_complete submission
Alzheimer's disease (AD) and most of other tauopathies are incurable neurodegenerative diseases with unpleasant symptoms and consequences. The common hallmark of all these diseases is tau pathology but its connection with disease progress has not been completely understood so far. Therefore, uncover...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-07 | PXD018687 | Pride
Mass spectrometry Alzheimer's disease In vivo crosslinking Tau interaction partners Tau protein Tauopathies Tau pathology 
ProteomicsAxonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease
Pathological deposition of hyperphosphorylated tau in the brain closely correlates with the course of Alzheimer´s disease (AD). Tau pathology occurs first in axons of affected neurons and tau removal from axons might thus be an early intervention strategy. We report that the RNA-binding protein hnRN...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD053387 | Pride
Antisense oligonucleotide Alzheimer´s disease Amyloid Tau Hnrnp r 
ProteomicsTruncated Tau - Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms
Tau is a microtubule-associated protein that ensures neuronal shape and function. Besides, Tau is a central player in Alzheimer’s disease (AD) and related Tauopathies where it is found aggregated in degenerating neurons. Mechanisms leading to Tau pathology and its progression are far from being eluc...
ORGANISM(S): Homo sapiens (Human) 
2015-05-15 | PXD001353 | Pride
Tau  alzheimer's disease  human  lc ms/ms 
ProteomicsThe interactome of tau phosphorylated at T217 in Alzheimers disease human brain tissue
Tau phosphorylation and aggregation are pathological features of Alzheimers disease. Tau phosphorylated at threonine 217 (pT217) and threonine 231 (pT231) are early fluid biomarkers of Alzheimers disease, suggesting early involvement in disease. However, little is known about the specific actions of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-11 | MSV000096377 | MassIVE
GenomicsMicroglial microRNAs mediate sex-specific responses to tau pathology
Microglial microRNAs mediate sex-specific responses to tau pathology
PRJNA558410 | ENA
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