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TranscriptomicsMG1655_temperature_O2_response_normalized_data_Tavazoie
Microarray transcriptional profiling was utilized to observe the global cellular state correlates of the physiological responses to temperature and oxygen changes. We provide evidence for the existence of correlations of Escherichia coli transcriptional responses to temperature and oxygen perturbat...
ORGANISM(S): Escherichia coli K12 
2008-05-13 | E-GEOD-10855 | biostudies-arrayexpress
TranscriptomicsFitness Landscape of Antibiotic Tolerance in Pseudomonas aeruginosa Biofilms
Bacteria in biofilms have higher antibiotic tolerance than their planktonic counterparts. A major outstanding question is the degree to which the biofilm-specific cellular state and its constituent genetic determinants contribute to this hyper-tolerant phenotype. Here, using genome-wide functional...
ORGANISM(S): Pseudomonas aeruginosa 
2011-11-21 | E-GEOD-26142 | biostudies-arrayexpress
TranscriptomicsBacterial Adaptation Through Loss of Function
Transcriptional profiling of mutants with beneficial in-frame null mutations. The goal of the study is to understand how expression of the mutants and their parental strain differs in conditions where the mutations are beneficial. For each of two conditions (media with either glutamine or alanine a...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-08-23 | E-GEOD-30345 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of the ethanol tolerant strain HG228 in comparison to its parental strain Escherichia coli MG1655
The goal of this experiment is to identify the pathways that are deregulated as part of an adaptive response to high levels of ethanol in the media. Ethanol tolerant cells (HG228) grown in minimal media plus 1.5% (v/v) ethanol were hybridized against E. coli MG1655 grown under similar conditions. Th...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2010-06-15 | E-GEOD-21194 | biostudies-arrayexpress
TranscriptomicsHNRPA2B1 HITS-CLIP
Expression, crosslinking and immunoprecipitation of tagged HNRPA2B1 (variant A2) to identify bound RNA sequences RNA molecules that are immunoprecipitated are sequenced followed purification under denaturing conditions
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-35799 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila embryos blastula wild-type and haploid
In most embryos, the mid-blastula transition is a complex process featuring maternal RNA degradation, cell cycle pause, zygotic transcriptional activation and morphological changes. The nucleocytoplasmic (N/C) ratio has been proposed to control the multiple events at MBT. To understand the global tr...
ORGANISM(S): Drosophila melanogaster 
2009-06-24 | E-GEOD-14287 | biostudies-arrayexpress
TranscriptomicsWhole-genome decay rate measurements in MDA-MB-231 cells transfected with HNRPA2B1 siRNAs versus controls
Transcriptional profiling of MDA-MB-231 samples taken at 0, 1, 2 and 4hr timepoints upon exposure to alpha-amanitine, comparing the siRNA-mediated HNRPA2B1 knock-downs versus mock-transfected controls 4 biological replicates for each time point for the siRNA transfections and controls respectively
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-35756 | biostudies-arrayexpress
TranscriptomicsNuclear HNRNPA2B1 HITS-CLIP and RNA-seq
To identify HNRNPA2B1 binding sites on endogenous nuclear RNAs, we performed HITS-CLIP for endogenous HNRNPA2B1 and RNA-seq to analyze the nuclear RNA under either METTL3 or HNRNPA2B1 depletion. Wild type MDA-MB-231 cells were subjected to the HITS-CLIP procedure on immunoprecipitated HNRNPA2B1 asso...
ORGANISM(S): Homo sapiens 
2015-06-20 | E-GEOD-70061 | biostudies-arrayexpress
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