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ProteomicsRegulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway C4PR_LIV
The ATR-CHK1 signalling pathway responds to single strand DNA breaks and is required for cancer cells to survive the high levels of DNA replication stress and genomic instability resulting from the activity of oncogenes such as MYC. For this reason, inhibitors of CHK1 have great potential as anti-c...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-19 | PXD026203 | Pride
Sps-ms3 Mouse Tmt Phosphorylation Lc-ms/ms 
TranscriptomicsRNAseq of tumor samples from CT26 syngeneic mouse treated with a PI3Ka/d inhibitor (AZD8835)
PI3K inhibitors with differential selectivity to distinct PI3K isoforms have been tested extensively in clinical trials, largely to target tumor epithelial cells. PI3K signaling also regulates the immune system and inhibition of PI3Kdelta modulate the tumor immune microenvironment of pre-clinical mo...
ORGANISM(S): Mus musculus 
2019-01-08 | E-MTAB-7386 | biostudies-arrayexpress
TranscriptomicsCustom MHC array analysis of lymphoblastoid cell lines
The human MHC is a paradigm for genomics, showing striking association with disease but functional variants remain largely unresolved. Using an original hybrid microarray (containing tiling and junction probes) for the MHC and accounting for known sequence diversity, we have drawn the first high-res...
ORGANISM(S): Homo sapiens 
2011-05-23 | E-GEOD-22453 | biostudies-arrayexpress
TranscriptomicsAffymetrix Human Exon 1.0 ST array analysis of lymphoblastoid cell lines
This experiment accompanies the main analysis using a custom MHC array to define the first high-resolution, strand-specific transcriptional map of the MHC, defining differences in gene expression for three common haplotypes associated with autoimmune disease. Unstimulated samples for each haplotype ...
ORGANISM(S): Homo sapiens 
2011-05-23 | E-GEOD-22454 | biostudies-arrayexpress
UnknownUrine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study.
Not available
S-EPMC7447976 | biostudies-literature
UnknownSystemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease
Not available
S-SCDT-10_1038-S44321-024-00092-4 | biostudies-other
TranscriptomicsComparison of post-mortem tissue from Brodman Brain BA22 region between schizophrenic and control patients
Transcriptional analysis of the superior temporal cortex (BA22) in schizophrenia: Pathway insight into disease pathology and drug development Schizophrenia is a highly debilitating psychiatric disorder which is known to have heritable genetic and environmental components. To gain some insight into t...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-21935 | biostudies-arrayexpress
TranscriptomicsFoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation
To understand the developing striatum, key genes during development were identified using microarray analsyis tha could be considered as marker of medium spiny neurons. The ages studied is at peak striatal neurogenesis. 3 different gestational ages of CD1 mice were used with triplicate repeats
ORGANISM(S): Mus musculus 
2016-06-23 | E-GEOD-55497 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of synovial tissue biopsies from individuals with rheumatoid arthritis from the STRAP randomised clinical trial
Transcriptomic profiles of synovial biopsies of rheumatoid arthritis (RA) patients recruited into the STRAP randomised clinical trial: RNA-Seq data from 210 patients at baseline. Patients were randomly assigned to etanercept, tocilizumab and rituximab. For the full study protocol and baseline patien...
ORGANISM(S): Homo sapiens 
2025-04-28 | E-MTAB-13733 | biostudies-arrayexpress
UnknownIntegrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.
Not available
S-EPMC5637314 | biostudies-literature
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