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MetabolomicsMetabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse (NMR assay)
Regulation between the fed and fasted state in mammals is partially controlled by peroxisome proliferator activated receptor-alpha (PPAR-alpha). Expression of the receptor is high in liver, heart and skeletal muscle, but decreases with age. A combined 1H NMR spectroscopy and GC-MS metabolomic approa...
2018-10-11 | MTBLS261 | MetaboLights
MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsMetabolomics Analysis Reveals Tissue-Specific Metabolite Compositions in Leaf Blade and Traps of Carnivorous Nepenthes Plants
Nepenthes is a genus of carnivorous plants that evolved a pitfall trap, the pitcher, to catch and digest insect prey to obtain additional nutrients. Each pitcher is part of the whole leaf, together with a leaf blade. These two completely different parts of the same organ were studied separately in a...
2020-07-10 | MTBLS1783 | MetaboLights
UnknownGenome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility.
Not available
S-EPMC6366343 | biostudies-literature
MetabolomicsComparative Analysis of Host Metabolic Alterations in Murine Malaria Models with Uncomplicated or Severe Malaria

Malaria varies in severity, with complications ranging from uncomplicated to severe malaria. Severe malaria could be attributed to peripheral hyperparasitemia or cerebral malaria. The metabolic interactions between the host and Plasmodium species are yet to be understood during these inf...

2022-09-14 | MTBLS4387 | MetaboLights
ProteomicsProteome of lysate granules using G3BP and ASPL, and changes in the G3BP interactome caused by ASPL depletion
Proteome of lysate granules using G3BP and ASPL, and changes in the G3BP interactome caused by ASPL depletion
ORGANISM(S): Homo sapiens (Human) 
2025-08-16 | PXD059889 | Pride
Ribonucleoprotein granule Aspscr1 Ubxd9 Tug Protein homeostasis Viscoelasticity Aspl Stress granule Rheology Vcp/p97 G3bp Ulk Multisystem proteinopathy 
UnknownA pilot to assess target engagement of terazosin in Parkinson's disease.
Not available
S-EPMC8862665 | biostudies-literature
UnknownPreliminary anti-cancer photodynamic therapeutic in vitro studies with mixed-metal binuclear ruthenium(II)-vanadium(IV) complexes.
Not available
S-EPMC3751419 | biostudies-literature
MetabolomicsThe genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

Cyclic peptides are reported to have antibacterial, antifungal and other bioactivities. Orbitides are a class of cyclic peptide that are small, head-to-tail cyclized, composed of proteinogenic amino acids, and lack disulfide bonds; they are also known in several genera of the plant family Rutacea...

2020-10-14 | MTBLS1963 | MetaboLights
UnknownLower resting state functional connectivity partially mediates adverse effects of prenatal alcohol exposure on arithmetic performance in children.
Not available
S-EPMC11998671 | biostudies-literature
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