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MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
ProteomicsULK1/2 DKO MEF phosphoproteomics
Autophagy is a mechanism by which intracellular cargo are catabolised in the lysosome. It involves the formation of double membraned organelles termed autophagosomes, a complex process orchestrated by the serine/threonine kinase ULK complex and class III PI3 kinase VPS34. Unbiased screens for ULK su...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-15 | PXD022228 | Pride
Phosphoproteomics Vps15 Vps34 P150 Pi3 kinase Autophagy Lc-ms/ms Pik3r4 Autophagosome Prkag2 Ulk2 Tmt Ulk1 Silac Amino acid starvation Mouse embryonic fibroblasts Orbitrap ulk1 
GenomicsONT ULK sequencing of a male cape dune mole-rat kidney sample
ONT ULK sequencing of a male cape dune mole-rat kidney sample
PRJEB122994 | ENA
UnknownPhosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy.
Not available
S-EPMC8280838 | biostudies-literature
GenomicsONT ULK sequencing of a male cape dune mole-rat kidney sample
One ONT-ULK sequencing run from the kidney of a single male CDMR (Bathyergus suillus) sample used to make the mBatSui1.1.primary genome assembly as an evolutionary comparator to our telomere-to-telomere naked mole-rat genome assembly. Specifically, we assembled a CDMR from a wild-derived sample in S...
ORGANISM(S): Bathyergus suillus 
2026-08-05 | E-MTAB-17420 | biostudies-arrayexpress
UnknownULK phosphorylation of STX17 controls autophagosome maturation via FLNA.
Not available
S-EPMC10316704 | biostudies-literature
UnknownULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.
Not available
S-EPMC2663920 | biostudies-literature
UnknownThe ingenious ULKs: expanding the repertoire of the ULK complex with phosphoproteomics.
Not available
S-EPMC8726633 | biostudies-literature
UnknownThe ULK complex-LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation.
Not available
S-EPMC9789397 | biostudies-literature
UnknownMolecular dynamics simulations provide insights into ULK-101 potency and selectivity toward autophagic kinases ULK1/2.
Not available
S-EPMC10705459 | biostudies-literature
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