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TranscriptomicsThe class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα
The class 3 phosphoinositide 3-kinase (PI3K) is required for the lysosomal degradation by autophagy and vesicular trafficking, assuring adaptation to energy shortages. Mitochondrial lipid catabolism is another important energy source. Autophagy and mitochondrial metabolism are transcriptionally cont...
ORGANISM(S): Mus musculus 
2020-02-06 | E-MTAB-7685 | biostudies-arrayexpress
UnknownStructure and function of Vps15 in the endosomal G protein signaling pathway.
Not available
S-EPMC2740480 | biostudies-literature
GenomicsA mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi
VPS15 is known as a VPS34-associated protein that functions in intracellular trafficking and autophagy. Here the authors identify a role for VPS15 in cilopathy and ciliary phenotypes, and show that it interacts with GM130 and functions in IFT20-dependent cis-Golgi to cilium trafficking.
EGAS00001002075 | EGA
UnknownStructural pathway for PI3-kinase regulation by VPS15 in autophagy.
Not available
S-EPMC11985297 | biostudies-literature
UnknownVps15 is required for stress induced and developmentally triggered autophagy and salivary gland protein secretion in Drosophila.
Not available
S-EPMC4326576 | biostudies-literature
UnknownPhosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy.
Not available
S-EPMC8280838 | biostudies-literature
UnknownA mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi.
Not available
S-EPMC5123056 | biostudies-literature
ProteomicsULK1/2 DKO MEF phosphoproteomics
Autophagy is a mechanism by which intracellular cargo are catabolised in the lysosome. It involves the formation of double membraned organelles termed autophagosomes, a complex process orchestrated by the serine/threonine kinase ULK complex and class III PI3 kinase VPS34. Unbiased screens for ULK su...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-15 | PXD022228 | Pride
Phosphoproteomics Vps15 Vps34 P150 Pi3 kinase Autophagy Lc-ms/ms Pik3r4 Autophagosome Prkag2 Ulk2 Tmt Ulk1 Silac Amino acid starvation Mouse embryonic fibroblasts Orbitrap ulk1 
UnknownMutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.
Not available
S-EPMC5897053 | biostudies-literature
ProteomicsA novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution
RAB5-GTP activation of the multiprotein VPS34 complex II (VPS34-CII) is critical for endosomal sorting and maturation, phagocytosis, and receptor downregulation. RAB5-GTP activates VPS34-CII, by binding to a helical insertion in the C2 domain of VPS34 on the BECLIN1/UVRAG-containing adaptor arm of t...
ORGANISM(S): Homo sapiens (Human) 
2026-05-26 | PXD061277 | Pride
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