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TranscriptomicsL-Glutamine metabolism and its regulation in C. glutamicum
Corynebacterium glutamicum, a gram-positive soil bacterium used for the industrial production of amino acids such as L-glutamate and L-lysine, is able to use a number of different nitrogen sources, such as ammonium, urea, or creatinine. In this communication, we show that L-glutamine serves as an ex...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2010-10-05 | E-GEOD-19779 | biostudies-arrayexpress
GenomicsGenome-Wide Transcriptome and Chromatin Analysis of Aspergillus nidulans Primary and Secondary Metabolism Reveals Crucial Function for a Kdm5-Family Histone Demethylase.
Histone posttranslational modifications (HPTMs) are involved in regulating the synthesis of fungal bioactive compounds. The exact molecular mechanisms of the silencing/activation of secondary metabolism (SM) clusters by these epigenetic events however are not yet fully understood. This work applies ...
ORGANISM(S): Aspergillus nidulans 
2016-04-01 | E-GEOD-72126 | biostudies-arrayexpress
TranscriptomicsExpression profiling of human adipose tissue derived stem cells cultured at various oxygen tensions
Adipose tissue is a plentiful and easily accessible source of mesenchymal stem cells that have been shown to be multi potent and possibly have immuno suppressive capacity(Zuk, Zhu et al. 2002; McIntosh, Zvonic et al. 2006; Prichard, Reichert et al. 2008). Several studies have identified hypoxia and ...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-12884 | biostudies-arrayexpress
TranscriptomicsAnalysis of genomic instability in esophageal squamous cell carcinoma (ESCC)
To characterize genomic instability in esophageal squamous cell carcinoma, we examined loss of heterozygosity, copy number loss, and copy number gain in ESCC patients from a high-risk region of China. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted fr...
ORGANISM(S): Homo sapiens 
2010-04-10 | E-GEOD-15526 | biostudies-arrayexpress
GenomicsIdentification of the primary target of the chemotherapeutic agent CX-5461 as a late step in transcription initiation by RNA Polymerase I
In recent years, several small molecule cytotoxic drugs have been identified as potential inhibitors of ribosome biogenesis (Drygin et al., 2011; Peltonen et al., 2014a; Peltonen et al., 2014b). CX-5461 is one such drug that has also demonstrated anticancer potential for a wide range of malignancies...
ORGANISM(S): Mus musculus 
2021-04-07 | E-MTAB-9242 | biostudies-arrayexpress
TranscriptomicsAffymetrix gene expression array data for cardia and non-cardia gastric cancer samples
We identified different and common dysregulated genes in cardia and non-cardia gastric cancer in the two type of gastric cancer cardia and non-cardia gastric tumors and normal glands
ORGANISM(S): Homo sapiens 
2013-07-19 | E-GEOD-29272 | biostudies-arrayexpress
UnknownCirculating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure.
Not available
S-EPMC4329085 | biostudies-literature
UnknownAn Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome.
Not available
S-EPMC9588491 | biostudies-literature
UnknownTri-culture system for pro-hapten sensitizer identification and potency classification.
Not available
S-EPMC6276108 | biostudies-literature
UnknownMicrodevice integrating innate and adaptive immune responses associated with antigen presentation by dendritic cells.
Not available
S-EPMC5909707 | biostudies-literature
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