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TranscriptomicsChIP-chip from H9 hESCs for RNA Polymerase II, TBP, TAF3, TAF5, TAF7, and TAF11
The general transcription factor TFIID is composed of the TATA-box-binding protein (TBP) and approximately 14 TBP-associated factors (TAFs). Here we find, unexpectedly, that undifferentiated human embryonic stem cells (hESCs) contain only six TAFs (TAFs 2, 3, 5, 6, 7 and 11), whereas following diffe...
ORGANISM(S): Homo sapiens 
2012-11-19 | E-GEOD-39312 | biostudies-arrayexpress
TranscriptomicsA compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes
Different mechanisms for CBF-MYH11 function in acute myeloid Leukemia (AML) with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly and recruitment of histone deacetylases, all resulting in transcriptional repression of ...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-46044 | biostudies-arrayexpress
UnknownDownstream promoter interactions of TFIID TAFs facilitate transcription reinitiation.
Not available
S-EPMC5749164 | biostudies-literature
UnknownMolecular evolution of the testis TAFs of Drosophila.
Not available
S-EPMC2727373 | biostudies-literature
OtherTAF10 interacts with GATA1 transcription factor and controls mouse erythropoiesis.
Data from ProteomeXchange, PXD ID: PXD000729. Experiment: hs, file: F049331.dat-pride.pride.mgf. Published as part of Mol Cell Biol. 2015 Apr 13 . From the Abstract: {{i}} The ordered assembly of a functional pre-initiation complex (PIC), composed of general transcription factors (GTFs), is a prere...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320015002 | GPMDB
Resource Reanalysis 
UnknownCharacterization of TBP and TAFs in Mungbean (Vigna radiata L.) and Their Potential Involvement in Abiotic Stress Response.
Not available
S-EPMC11394781 | biostudies-literature
GenomicsIdentification of genomic binding sites of a network of core promoter factors in developing Drosophila brains
The transcriptional mechanisms that allow neural stem cells (NSC) to balance self-renewal with differentiation are not well understood. We identify here a unique subset of TATA -binding protein associated factors (TAFs) as NSC identity genes in Drosophila. We found that depletion of any one of nine ...
ORGANISM(S): Drosophila melanogaster 
2019-04-01 | GSE120432 | GEO
TranscriptomicsIdentification of transcriptional targets of a network of Drosophila core promoter factors in neural stem cells
The transcriptional mechanisms that allow neural stem cells (NSC) to balance self-renewal with differentiation are not well understood. We identify here a unique subset of TATA -binding protein associated factors (TAFs) as NSC identity genes in Drosophila. We found that depletion of any one of nine ...
ORGANISM(S): Drosophila melanogaster 
2019-04-01 | GSE120430 | GEO
GenomicsChIP-chip from H9 hESCs for RNA Polymerase II, TBP, TAF3, TAF5, TAF7, and TAF11
The general transcription factor TFIID is composed of the TATA-box-binding protein (TBP) and approximately 14 TBP-associated factors (TAFs). Here we find, unexpectedly, that undifferentiated human embryonic stem cells (hESCs) contain only six TAFs (TAFs 2, 3, 5, 6, 7 and 11), whereas following diffe...
ORGANISM(S): Homo sapiens 
2012-11-19 | GSE39312 | GEO
ProteomicsImportance of TAF8 regions for TFIID lobe B assembly, or for TAF2 interactions, are required for embryonic stem cell survival
The human general transcription factor TFIID is composed of the TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). In eukaryotic cells, TFIID is thought to nucleate RNA polymerase II (Pol II) preinitiation complex formation on all protein coding gene promoters and thus, be crucial for ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028352 | Pride
Tata binding protein (tbp) Tbp-associated factors (tafs) Viability Knock out Function Taf8 Structure Tfiid Crispr/cas9 Baculovirus over expression Embryonic stem cells (escs) Taf complexes 
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