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GenomicsGenome-wide maps of Tbx3 binding sites in mouse ESCs
Induced pluripotent stem (iPS) cells can be obtained through the introduction of defined factors into somatic cells. The combination of Oct4, Sox2 and Klf4 (OSK) constitutes the minimal requirement for generating iPS cells from mouse embryonic fibroblasts (MEFs). Through the genomic analyses of ESC ...
ORGANISM(S): Mus musculus 
2009-12-04 | E-GEOD-19219 | biostudies-arrayexpress
TranscriptomicsTbx3 controls Dppa3 levels to regulate exit from pluripotency towards mesodermal lineage
Tbx3, a member of the T-box family, plays important roles in development, stem cells, nuclear reprogramming and cancer. Loss of Tbx3 induces differentiation in mouse embryonic stem cells (mESCs). However, we show that mESCs exist in an alternate stable pluripotent state in the absence of Tbx3. In-de...
ORGANISM(S): Mus musculus 
2015-07-21 | E-GEOD-60066 | biostudies-arrayexpress
ProteomicsBioID-MS of TBX3-proximal proteins in HEK293T cells
Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action of nuclear b-catenin. Yet, little is known about how b-catenin generates context-specific transcriptional outcomes. Addressing this knowledge gap is pivotal since neopla...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD047899 | Pride
Tbx3 Hek293t Wnt Bioid 
GenomicsThe histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation
Here we show that T-box proteins team up with chromatin modifying enzymes to drive the expression of the key lineage regulator, Eomes during endodermal differentiation of embryonic stem (ES) cells. The Eomes locus is maintained in a transcriptionally poised configuration in ES cells. During early di...
ORGANISM(S): Mus musculus 
2013-04-18 | E-GEOD-44764 | biostudies-arrayexpress
TranscriptomicsCoordinated control of senescence by lncRNA UCA1 and a novel CAPERα/TBX3 co-repressor
Coordination of a complex series of transcriptional, structural and signaling events culminates in cellular senescence, a crucial tumor suppressor mechanism. We have discovered a repressor complex composed of TBX3 and CAPERa which functions upstream of the RB and p53 effector pathways and is require...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-76572 | biostudies-arrayexpress
GenomicsChIP-seq experiment of the beta-catenin co-factor BCL9 and the T-box transcription factor TBX3 in developing mouse forelimbs.
About 500 forelimbs were isolated at 10.5 days post coitum, and ChIP-seq was performed using anti-BCL9 (Abcam, ab37305) and anti-TBX3 (Santacruz, sc17871) antibodies. BCL9 is a beta-catenin transcriptional cofactor involved in the transcriptional machinery of Wnt target genes. TBX3 is a transcriptio...
ORGANISM(S): Mus musculus 
2020-05-08 | E-MTAB-8997 | biostudies-arrayexpress
TranscriptomicsExpression profiling of the forming atrioventricular node using a novel Tbx3-based node-specific transgenic reporter
The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV node-specific reporter mouse to gain insight into the gene programs determining the forma...
ORGANISM(S): Mus musculus 
2009-06-02 | E-GEOD-13614 | biostudies-arrayexpress
GenomicsGenome-wide occupancy profile of Tbx3 in adult mouse whole heart
The contraction pattern of the heart relies on the activation and conduction of the electrical impulse. Perturbations of cardiac conduction have been associated with congenital and acquired arrhythmias as well as cardiac arrest. The pattern of conduction depends on the regulation of heterogeneous ge...
ORGANISM(S): Mus musculus 
2013-03-05 | E-GEOD-44821 | biostudies-arrayexpress
GenomicsGenome-wide occupancy profile of Tbx3, Gata4, Nkx2-5 and p300 in adult mouse whole heart
The contraction pattern of the heart relies on the activation and conduction of the electrical impulse. Perturbations of cardiac conduction have been associated with congenital and acquired arrhythmias as well as cardiac arrest. The pattern of conduction depends on the regulation of heterogeneous ge...
ORGANISM(S): Mus musculus 
2012-06-22 | E-GEOD-35151 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse luminal mammary epithelial cells
We used a mouse strain in which one Tbx3 gene was replaced with the yellow fluorescent protein variant Venus. Luminal cells had either very high Tbx3 promoter activity or not at all. We performed an expression analysis on luminal mammary epithelial cells sorted based on their Venus expression (repor...
ORGANISM(S): Mus musculus 
2014-08-20 | E-GEOD-58327 | biostudies-arrayexpress
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