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ProteomicsProteome analysis in the TcMAC21 mouse model of Down syndrome
Down syndrome (DS) results from trisomy of human chromosome 21 (HSA21), and DS research has been greatly advanced by the use of mouse models. We previously generated a humanized mouse model of DS, TcMAC21, which carries the long arm of HSA21. These mice exhibit learning and memory deficits, and may ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-23 | PXD044343 | Pride
Lc-msms Down syndrome Phospho-proteome Tcmac21 
UnknownTcMAC21 mouse model recapitulates abnormal vascular physiology observed in humans with Down syndrome.
Not available
S-EPMC12141928 | biostudies-literature
UnknownNeocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome.
Not available
S-EPMC10679816 | biostudies-literature
GenomicsPostnatal day 6 cerebellum of Ts65Dn and TcMAC21 Down syndrome mouse models
Postnatal day 6 cerebellum of Ts65Dn and TcMAC21 Down syndrome mouse models
PRJNA837794 | ENA
Genomics
Gene expression analyses of TcMAC21 mice
PRJNA877694 | ENA
TranscriptomicsPostnatal day 6 cerebellum of Ts65Dn and TcMAC21 Down syndrome mouse models
Dysregulation of Sonic hedgehog (SHH) signaling may contribute to multiple Down syndrome-associated phenotypes, including cerebellar hypoplasia, congenital heart defects, craniofacial and skeletal dysmorphologies, and Hirschsprung disease. Granule cell precursors isolated from the developing cerebel...
ORGANISM(S): Mus musculus 
2022-05-16 | GSE202938 | GEO
UnknownA non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21.
Not available
S-EPMC7358007 | biostudies-literature
UnknownHypermetabolism in mice carrying a near complete human chromosome 21.
Not available
S-EPMC9915508 | biostudies-literature
UnknownHypermetabolism in mice carrying a near-complete human chromosome 21.
Not available
S-EPMC10229126 | biostudies-literature
UnknownAltered motor coordination, vocal communication, and cerebellar circuit connectivity in mice carrying a near-complete human chromosome 21.
Not available
S-EPMC12789671 | biostudies-literature
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