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TranscriptomicsTDP-43 Neurotoxicity in late D. melanogaster pupae
The aim of this study is to understand the mechanisms of TDP-43 neurotoxicity. Here, we perform a RNA-Seq analysis in TDP-43 gain-of-fucntion (GOF) , TDP-43 loss-of-function and wild-type late pupae heads (73-90 hours APF) and perform TDP-43 GOF vs wild type and TDP-43 LOF vs wild-type differential...
ORGANISM(S): Drosophila melanogaster 
2013-01-22 | E-GEOD-42844 | biostudies-arrayexpress
TranscriptomicsLoss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons [NSC34]
Aims: Loss of nuclear TDP-43 characterises sporadic and most familial forms of amyotrophic lateral sclerosis (ALS). TDP-43 (encoded by TARDBP) has multiple roles in RNA processing. We aimed to determine whether 1) RNA splicing dysregulation is present in lower motor neurons in ALS and in a motor neu...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-56503 | biostudies-arrayexpress
ProteomicsNucleolin rescues TDP-43 toxicity in yeast and human cell models
TDP-43 is a nuclear protein involved in pivotal processes, extensively studied for its implication in neurodegenerative disorders. TDP-43 cytosolic inclusions are a common neuropathologic hallmark in amyotrophic lateral sclerosis (ALS) and related diseases, and it is now established that TDP-43 misf...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-03-26 | PXD022432 | Pride
Nucleolin Tmt Als Nucleo-cytoplasmic transport Ftd Tdp-43 proteinopathies Lc-hrms/ms Neurodegenerative disorders 
ProteomicsTDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis
Single cell dataset of human motor neurons laser-captured from postmortem ALS and control tissues (1) ALS Pilot dataset (2) TDP43 stratified dataset Summary: Unbiased proteomics has been employed to interrogate central nervous system (CNS) tissues (brain, spinal cord) and fluid matrices (CSF, plas...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-07 | MSV000092119 | MassIVE
ProteomicsA neurotoxic cryptic peptide arising from TDP-43-dependent cryptic splicing of PKN1
Transactive response DNA-binding protein 43 (TDP-43) is a key factor in maintaining the fidelity of neuronal RNA splicing, and its dysfunction is observed in amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) with TDP-43 pathology. Although loss of TDP-43 can activate multiple cryptic ...
ORGANISM(S): Mus Musculus 
PXD069368 |
ProteomicsShort RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
Aberrant aggregation of the prion-like RNA-binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). Here, we define how short, specific RNAs solubilize TDP-43. These short RNAs engage and stabilize the TDP-43 RNA-recognition motifs...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2026-05-15 | PXD071117 | Pride
Tdp-43 Hydrogen/deuterium-exchange mass spectrometry Rna 
ProteomicsDetection and Quantification of Novel C-terminal TDP-43 Fragments in ALS-TDP
The pathological hallmark of amyotrophic lateral sclerosis (ALS) is the presence of cytoplasmic inclusions, containing C-terminal fragments of the protein TDP-43. Here, we tested the hypothesis that highly sensitive mass spectrometry with parallel reaction monitoring (MS-PRM) can generate a high-res...
ORGANISM(S): Homo sapiens (Human) 
2020-12-17 | PXD022186 | Pride
Prm Tdp-43 Als 
ProteomicsNative State Stabilization is an Effective Strategy to Inhibit TDP-43 Oligomerization and Fibrillogenesis
Transactive response DNA-binding protein 43 kDa (TDP-43) is a partially disordered nuclear protein that plays essential roles in RNA metabolism to maintain cellular homeostasis. In individuals with neurodegenerative diseases (NDDs), including Amyotrophic lateral Sclerosis (ALS), Alzheimer’s disease,...
ORGANISM(S): Homo sapiens (Human) Bacteria 
2026-06-24 | PXD041160 | Pride
Hdx-ms Aggregation Neuronal toxicity Oligonucleotides Tar dna binding protein (tdp-43) 
ProteomicsProteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport
Transactive response DNA-binding protein 43 (TDP-43) is a predominantly nuclear, ubiquitously expressed RNA and DNA-binding protein. It recognises and binds to UG repeats and is involved in pre-mRNA splicing, mRNA stability and microRNA metabolism. TDP-43 is essential in early embryonic development ...
ORGANISM(S): Homo sapiens (Human) 
2015-06-29 | PXD001668 | Pride
Intracellular transport Tdp-43 Comparative proteomics Amyotrophic lateral sclerosis Frontotemporal lobar degeneration Ranbp1 
UnknownDrosophila Answers to TDP-43 Proteinopathies.
Not available
S-EPMC3337594 | biostudies-literature
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