Sort   by:  
 Page size 
MetabolomicsTear lipidomics profiling reveals inflammatory dry eye disease-associated lipid metabolic remodeling at the ocular surface
This study aimed to investigate whether inflammatory dry eye disease (DED) is accompanied by abnormal lipid metabolic remodeling at the ocular surface. Tear samples were collected from patients with DED and matched healthy controls. Lipidomics profiling was performed using LC–MS/MS with a standardiz...
2026-04-03 | MTBLS14218 | MetaboLights
MetabolomicsTear lipidomics profiling reveals ocular-surface lipid remodeling associated with organelle stress in a mouse model of inflammatory dry eye disease
This study aimed to determine whether dry eye disease (DED) is accompanied by ocular-surface lipid remodeling and whether such changes converge on organelle stress–associated pathways in a mouse model of inflammatory dry eye. Tear samples were collected from mice and analyzed by LC–MS/MS–based non-t...
2026-04-04 | MTBLS14217 | MetaboLights
ProteomicsInvestigation of inter- and intra-day variability of tear fluid regarding flow rate, protein concentration as well as protein composition
Purpose: Determination of inter- and intra-day variations in tear flow rate, tear fluid protein concentration as well as protein composition regarding their impact for future biomarker studies.Methods: Tear fluid was collected non-invasively from 18 healthy subjects performing Schirmer tests at four...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037811 | Pride
Mass spectrometry Tear fluid Schirmer test Tear flow rate  tear volume Protein concentration 
ProteomicsAspergillus flavus Induced Alterations in Tear Protein Profile Reveal Pathogen-Induced Host Response to Fungal Infection
Aspergillus flavus and Fusarium sp. are primary causative agents of keratitis that results in corneal tissue damage leading to vision loss. The tear proteome of control and keratitis patients was profiled and compared. A total of 1873 proteins from control and 1400 proteins from patient tear were id...
ORGANISM(S): Homo sapiens (Human) 
2016-12-13 | PXD003825 | Pride
Mycotic keratitis  tear proteomics  complement  netosis  wound healing  glycosylation 
ProteomicsTear Proteome Analysis Using LC-MS/MS in Patients with Primary Nasolacrimal Duct Obstruction
The pathogenesis of primary acquired nasolacrimal duct obstruction (PANDO) remains unclear, with several factors implicated, including anatomical structures, hormones, and tear components. This study explores tear proteins to better understand PANDO etiology by comparing protein expression in tears ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD063414 | Pride
Tear proteomics Nasolacrimal duct obstruction Epiphora 
ProteomicsLectin-based affinity enrichment and characterization of N-glycoproteins from the human tear film by mass spectrometry
Glycosylation of proteins is one of the most common post-translational modification (PTM) and plays important regulatory functions in diverse biological processes such as protein stability or cell signaling. Accordingly, glycoproteins are also a consistent part of the human tear film proteome mainta...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2023-01-25 | PXD038280 | Pride
N-glycoproteins Mass spectrometry Pngase f Tear film Multi-lectin column 
ProteomicsComparative analysis of tear proteomics in PAX6 mutant and control mice of both sexes before and after abrasion
Our team is working on aniridia, an autosomal dominant condition and has used a mouse model. The cornea, the eye’s first avascular and transparent optical surface, is covered by a stratified epithelium that constantly renews itself; any disruption compromises transparency and threatens vision. The t...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD070553 | Pride
Tear proteomics Wound healing Pax6 Aniridia 
UnknownInvestigation of Inter- and Intra-Day Variability of Tear Fluid Regarding Flow Rate, Protein Concentration as well as Protein Composition.
Not available
S-EPMC10573576 | biostudies-literature
ProteomicsTear Fluid Proteomics: A Comparative Study of DIA and DDA Mass Spectrometry
Background: Mass spectrometry is a powerful technique for tear fluid proteomics, offering critical insights into its complex molecular composition. Data-dependent acquisition (DDA), the most commonly used approach, preferentially selects high-abundance proteins, limiting reproducibility and the quan...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-10-20 | PXD062422 | Pride
Tear fluid  schirmer strip  proteomics  biomarkers  mass spectrometry 
ProteomicsTear proteome analysis by LC-MS/MS
We have analysed the tear proteome from multiple volunteers without ocular disease using untargeted LC-MS/MS with and without pre-fractionation of peptide digests. Standard LC-MS/MS was compared to results from fractionation by mixed-mode cation exchange SPE and reverse-phase HPLC fractionation. The...
ORGANISM(S): Homo sapiens (Human) 
2023-09-01 | PXD041752 | Pride
Tear proteome Data-dependent acquisition Proteomics Lc-ms/ms 
Sort   by:  
 Page size