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ProteomicsLectin-based affinity enrichment and characterization of N-glycoproteins from the human tear film by mass spectrometry
Glycosylation of proteins is one of the most common post-translational modification (PTM) and plays important regulatory functions in diverse biological processes such as protein stability or cell signaling. Accordingly, glycoproteins are also a consistent part of the human tear film proteome mainta...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2023-01-25 | PXD038280 | Pride
N-glycoproteins Mass spectrometry Pngase f Tear film Multi-lectin column 
ProteomicsN-glycoproteomic analyses from different insect species reveal conserved and unique glycoproteins
N-glycosylation is one of the most abundant and conserved protein modifications in eukaryotes. This modification serves various important functions, such as protein folding and cellular attachment, but also modulation of a protein’s function. Recently, it has been show...
ORGANISM(S): Buchnera aphidicola subsp. Acyrthosiphon pisum (Acyrthosiphon pisum symbiotic bacterium) Drosophila melanogaster (Fruit fly) Tetropium castaneum 
2018-06-18 | PXD008745 | Pride
Glycoprotein Mass spectrometry (ms) Proteomics Drosophila melanogaster Insect Pest insect Lectin N-linked glycosylation 
ProteomicsSite-specific N-glycosylation of HeLa cell glycoproteins
HeLa cell line is frequently used in biomedical research, however little is known about N-glycan structures expressed on individual glycoproteins of this complex sample. We characterized site-specific N-glycosylation of HeLa N-glycoproteins using a complex workflow based on high and low energy tande...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2019-10-21 | PXD013930 | Pride
Hela Nanouhplc-ms/ms N-glycosylation Site-specific 
ProteomicsIn-depth site-specific O-glycosylation analysis of glycoproteins and endogenous peptides in cerebrospinal fluid (CSF) from healthy individual mild cognitive impairment (MCI) and Alzheimer disease (AD) patients
Site-specific O-glycoproteome mapping in complex biological system provides molecular basis for understanding the structure-function relationships of glycoproteins and their roles in physiological and pathological processes. Previous O-glycoproteome analysis in cerebrospinal fluid (CSF) focused on s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-05 | MSV000087160 | MassIVE
ProteomicsLC-MS/MS Isomeric Profiling of N-Glycans derived from Low-Abundant Serum Glycoproteins in Mild Cognitive Im-pairment Patients
Mild cognitive impairment (MCI) is an early stage of memory loss that affects cognitive abilities, such as language or virtual/spatial comprehension. This cognitive decline is mostly ob-served with the aging of individuals. Recently, MCI has been considered as a prodromal phase of Alzheimer’s diseas...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036704 | Pride
Mci Biomarker glycan Neurological disorder Isomeric n-glycans 
UnknownAnalysis of N-glycoproteins using genomic N-glycosite prediction.
Not available
S-EPMC4072220 | biostudies-literature
ProteomicsEnhanced Quantitative LC-MS/MS Analysis of N-linked Glycans Derived from Glycoproteins Using Sodium Deoxycholate Detergent
Protein glycosylation is a common protein post-translational modification (PTM) in living organisms and has been shown to associate with multiple diseases, and thus may potentially be a biomarker of such diseases. Efficient protein/glycoprotein extraction is a key step in the preparation of N-glycan...
ORGANISM(S): Homo sapiens (Human) 
2018-05-16 | PXD008687 | Pride
Acidic labile detergent Detergent removal Lc-ms/ms sample preparation N-glycomics Sodium deoxycholate 
UnknownGlobal Profiling of N-Glycoproteins and N-Glycans in the Diatom Phaeodactylum tricornutum.
Not available
S-EPMC8678454 | biostudies-literature
ProteomicsA chemoenzymatic method for simultaneous profiling N- and O-glycans on glycoproteins using one-pot format
Glycosylation, including N-glycosylation and O-glycosylation is generally characterized and controlled as a critical quality attribute for therapeutic glycoproteins because glycans can impact protein-based drug product efficacy, half-life, stability, and safety. Analytical procedures to characterize...
ORGANISM(S): Bos taurus (Bovine) 
2024-08-01 | PXD052172 | Pride
Glycomics Glycoproteomics Fetuin 
UnknownSite-specific N-glycosylation of HeLa cell glycoproteins.
Not available
S-EPMC6794373 | biostudies-literature
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