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MetabolomicsTear lipidomics profiling reveals inflammatory dry eye disease-associated lipid metabolic remodeling at the ocular surface
This study aimed to investigate whether inflammatory dry eye disease (DED) is accompanied by abnormal lipid metabolic remodeling at the ocular surface. Tear samples were collected from patients with DED and matched healthy controls. Lipidomics profiling was performed using LC–MS/MS with a standardiz...
2026-04-03 | MTBLS14218 | MetaboLights
MetabolomicsTear lipidomics profiling reveals ocular-surface lipid remodeling associated with organelle stress in a mouse model of inflammatory dry eye disease
This study aimed to determine whether dry eye disease (DED) is accompanied by ocular-surface lipid remodeling and whether such changes converge on organelle stress–associated pathways in a mouse model of inflammatory dry eye. Tear samples were collected from mice and analyzed by LC–MS/MS–based non-t...
2026-04-04 | MTBLS14217 | MetaboLights
TranscriptomicsmicroRNA expression data from human corneal epithelial cells exposed to media, human tear, media + P. aeruginosa antigens, tear + P. aeruginosa antigens
Exposure to tear fluid can enhance corneal epithelial cells' ability to resist bacterial virulence mechanisms by upregulating epithelial-derived innate defense genes. The aim of this study was to further elucidate the mechanisms by which tear fluid modulates epithelial cell susceptibility to P. aeru...
ORGANISM(S): Homo sapiens 
2012-07-13 | E-GEOD-39341 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat lacrimal gland samples from normal, sham and operated animals
Previous studies showed that loss of muscarinic parasympathetic input to the lacrimal gland (LG) leads to a dramatic reduction in tear secretion and profound changes to LG structure. In this study, we used DNA microarrays to examine the regulation of the gene expression of the genes for secretory fu...
ORGANISM(S): Rattus norvegicus 
2007-10-12 | E-GEOD-844 | biostudies-arrayexpress
ProteomicsSystematic Investigation of Targeted Analysis of Metabolites and Proteins in Tear Fluid
Since the sampling of tear fluid seems rather variable we sought to evaluate a protocol for combined metabolomic and proteomic analyses with regard to clinical applicability. Tear fluid was taken from twelve human volunteers at different time points using specially designed Schirmer strips. Followin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD008536 | Pride
Tear fluid 
ProteomicsEye opening discoveries: uncovering lacritin glycoforms and the tear fluid glycoproteome
Tear fluid comprises a diverse group of extracellular glycoproteins which are critical for ocular homeostasis. Within the tear fluid glycoproteome, lacritin is highly expressed and plays a key role in immune response, tear secretion, and antimicrobial activity. Importantly, glycosylation constitutes...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD064788 | Pride
Glycoproteomics Mucin Mucinase Lacritin Mass spectrometry Immunoglobulin a Tear fluid 
GenomicsA gatekeeper mechanism of the noradrenergic neural control of tear secretion via the NA-Adra1a-Ucp2 pathway
A gatekeeper mechanism of the noradrenergic neural control of tear secretion via the NA-Adra1a-Ucp2 pathway
PRJNA931311 | ENA
TranscriptomicsA gatekeeper mechanism of the noradrenergic neural control of tear secretion via the NA-Adra1a-Ucp2 pathway
Tears are mainly secreted from the lacrimal gland under precise controls by autonomic neural response to external sensory and psychogenic emotional stimulation. Dynamic volume and compositional changes of tears may lead to development of dry eye disease. The role of sympathetic nerve system (SNS) in...
ORGANISM(S): Mus musculus 
2025-05-08 | GSE224484 | GEO
ProteomicsHigh throughput tear proteomics with data independent acquisition enables biomarker discovery in allergic conditions
The search for pathological biomarkers in biological fluids that can provide valuable insight into an individual’s health status, is a relevant area of research for multiple pathologies. Currently, the use of proteomics for the identification of differences in protein expression profiles between sam...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD067099 | Pride
Diapasef. High-throughput proteomics Tear secretion Biomarkers 
UnknownDiadenosine tetraphosphate contributes to carbachol-induced tear secretion.
Not available
S-EPMC4336306 | biostudies-literature
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