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ProteomicsTec kinase deficiency in macrophages
Previous work has shown conflicting roles for Tec family kinases in regulation of Toll-like receptor (TLR)-dependent signalling in myeloid cells. In the present study, we performed a detailed investigation of the role of Btk and Tec kinases in regulating TLR signalling in several types of primary mu...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD002031 | Pride
Tec kinase macrophage 
ProteomicsLysine Acetylation Dynamics
Cultured carcinoma cells were stimulated with growth factors and lysine acetylation and/or tyrosine phosphorylation dynamics were quantified.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079965 | MassIVE
TranscriptomicsRev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription
Rev-Erba and Rev-Erbb are nuclear receptors that regulate the expression of genes involved in the control of circadian rhythm, metabolism, and inflammatory responses. Rev-Erbs function as transcriptional repressors by recruiting NCoR/HDAC3 co-repressor complexes to Rev-Erb response elements in enha...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-45914 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of responses to infectious salmon anemia virus infection in macrophage-like cells
The aquatic orthomyxovirus infectious salmon anemia virus (ISAV) is an important pathogen for salmonid aquaculture, however little is known about protective and pathological host responses to infection. We have investigated intracellular responses during cytopathic ISAV infection in the macrophage-l...
ORGANISM(S): Salmo salar 
2008-04-16 | E-GEOD-11160 | biostudies-arrayexpress
TranscriptomicsA Systematic Approach to Identify Markers of Distinctly Activated Human Macrophages
Polarization has been a useful concept for describing activated macrophage phenotypes and gene expression profiles. However, macrophage activation status within tumors and other settings are often inferred based on only a few markers. Complicating matters for relevance to human biology, many of th...
ORGANISM(S): Homo sapiens 
2015-05-14 | E-GEOD-68854 | biostudies-arrayexpress
TranscriptomicsTranscriptional Response of Candida albicans Cells Following Phagocytosis by Mouse Macrophages
Transcriptional profiling of Candida albicans that had been phagocytosed for 1, 2, or 4 hours by either bone marrow-derived mouse macrophaged (BMDM) or immortalized RAW264.7 cells Keywords: Time course Two-condition experiment, phagocytosed cells vs cells maintained in D-10 media. Time course: 1, 2,...
ORGANISM(S): Candida albicans 
2008-07-28 | E-GEOD-11399 | biostudies-arrayexpress
TranscriptomicsAffymetrix gene expression of Transitional Type-1 B-cells from Wild-type (CBA), Xid and Btk KO mice
Splenic Transitional Type-1 B-cells from CBA wild-type mice, X-linked immunodeficiency mice and Bruton's tyrosine kinase knock-out mice. Two replicates where run on Affymetrix 420 2.0 arrays for CBA wild-type, Xid samples and the Btk KO samples. Bruton's tyrosine kinase (Btk) is a cytoplasmic tyros...
ORGANISM(S): Mus musculus 
2014-01-10 | E-GEOD-53946 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of brain macrophage subsets and peripheral blood monocytes in traumatic brain injury
We compared arginase-1+ macrophages (macrophages were defined by flow cytometry as CD45hi CD11b+ Ly6G-) with arginase-1- brain macrophages following traumatic brain injury (TBI) by isolating these cells from YARG transgenic mice, which express YFP under the arginase-1 promoter. Both cell populations...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-39759 | biostudies-arrayexpress
ProteomicsDefining targets of the bacterial ADP-ribosyltransferase EspJ
Tyrosine phosphorylation is key for signal transduction from exogeneous stimuli, including the defence against pathogenic microbes. Pathogens have acquired mechanisms to subvert protein phosphorylation as a means to control host immune responses and facilitate invasion and dissemination. The bacteri...
ORGANISM(S): Homo sapiens (Human) 
2018-03-16 | PXD008533 | Pride
Ehec Human Adp-ribosyltransferase Lc-ms/ms 
TranscriptomicsImmunoproteasome dysfunction augments alternative polarization of alveolar macrophages
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-72000 | biostudies-arrayexpress
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