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ProteomicsThe Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi
We quantified the proteome of Dsc complex mutants (tul1gld1) and ESCRT mutants (vps4). Therefore we used stable isotope labeling with amino acids in cell culture (SILAC) to identify changes in the membrane proteome of tul1gld1orvps4 cells relative to WT cells or gld1 cells (labeled with “heavy” [13C...
ORGANISM(S): Candida albicans (Yeast) 
2025-05-07 | PXD055553 | Pride
Degron Dsc complex Quality control Escrt Golgi Lipids Ubiquitin 
ProteomicsTXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
Entry and exit from cellular quiescence require dynamic adjustments in nutrient acquisition, yet the mechanisms by which quiescent cells downregulate amino acid (AA) transport remain poorly understood. Here we show that cells entering quiescence selectively target plasma membrane-resident AA transpo...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD066527 | Pride
Nutrient transporter Hect-type ubiquitin ligase Ppxy Quiescence Arrestin Endocytosis 
TranscriptomicsTranscription profiling of human EBV transformed cell lines established from patients with a novel immunodeficiency syndrome
Lysosome-related organelles have versatile functions including protein and lipid degradation, signal transduction, and protein secretion. The molecular elucidation of rare congenital diseases affecting endosomal/lysosomal biogenesis has given insights into physiological functions of the innate and a...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6322 | biostudies-arrayexpress
UnknownCoordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation
Not available
S-JCBD-201310114 | bioimages
UnknownThe late endosomal p14–MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration
Not available
S-JCBD-201310043 | bioimages
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