Sort   by:  
 Page size 
ProteomicsProteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased translation, keratinocyte-immune crosstalk and disordered axon guidance
Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads to atopic inflammation remain incompletely understood. Sk...
ORGANISM(S): Homo sapiens (Human) 
2019-08-14 | PXD014875 | Pride
Atopic eczema Skin Human 
ProteomicsSILAC-based quantitative proteomic analysis of Drosophila gastrula stage embryos mutant for fibroblast growth factor signalin
Quantitative mass spectrometry-based proteomic analyses in combination with genetics provide powerful tools in developmental cell signaling research. Drosophila melanogaster is one of the most widely used genetic models for studying development and disease. Here we combined quantitative proteomics w...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-09-09 | PXD016438 | Pride
Silac Drosophila 
ProteomicsEMSY expression affects multiple components of skin barrier with relevance to atopic dermatitis
Atopic dermatitis (AD) is a heritable inflammatory disease, characterised by skin barrier dysfunction. Genome-wide association studies (GWAS) have identified molecular targets with relevance for drug development, but the strongest genetic association, FLG, has not yet been successfully targeted in a...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD014088 | Pride
Human Skin Proteomics Organotypic culture 
MetabolomicsDeep insights into microsampling technologies for global lipidomic profiling of human whole blood using high-throughput LC-MS

In recent years, blood microsampling (BμS) technologies have gained popularity, as they offer simplicity, minimal invasiveness, and suitability for remote sample collection. In this study, the aim was to explore the potential of three BμS devices for reliable untargeted lipidomic profiling using ...

2025-09-30 | MTBLS10722 | MetaboLights
ProteomicsPlant SILAC: Stable-Isotope Labelling with Amino Acids of Arabidopsis Seedlings for Quantitative Proteomics.
Stable Isotope Labelling by Amino acids in Cell culture (SILAC) is a powerful technique for comparative quantitative proteomics, which has recently been applied to a number of different eukaryotic organisms. Inefficient incorporation of labelled amino acids in cell cultures of Arabidopsis thaliana h...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2016-08-15 | MSV000080043 | MassIVE
UnknownCerebellar Transcranial Direct Current Stimulation in Spinocerebellar Ataxia Type 3: a Randomized, Double-Blind, Sham-Controlled Trial.
Not available
S-EPMC9059914 | biostudies-literature
TranscriptomicsResponse of a resistant pea accesion to Mycosphaerella pinodes
Plants of the resistant Pisum sativum subsp. syriacum accession P665 and the susceptible pea cultivar Messire were inoculated with M. pinodes.The experiment was conducted in three replicates. 16, 24 and 48 hours after inoculation RNA was isolated from leaves of infected plants and transcribed into c...
ORGANISM(S): Pisum sativum 
2011-08-24 | E-TABM-1084 | biostudies-arrayexpress
ProteomicsHypoxia-induced proteomic remodeling of human mammary cancer associated fibroblast
Intratumoral hypoxia causes the formation of dysfunctional blood vessels which contribute to tumor metastasis. Blood vessels are embedded in the tumor stroma where cancer-associated fibroblasts (CAFs) constitute the most prominent cellular component. We found that hypoxic human mammary CAFs promote ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD006535 | Pride
Breast cancer  caf  proteomics  secretome  hypoxia  angiogenesis 
ProteomicsIn vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis
Cancer progresses through distinct stages and mouse models recapitulating traits of this progression are frequently used to explore genetic, morphological and pharmacological aspects of tumor development. To complement genomic investigations of this process, here we quantify phosphoproteomic changes...
ORGANISM(S): Mus musculus (Mouse) 
2013-03-13 | PXD000821 | Pride
Mouse Silac Phosphoproteomics Skin carcinogenesis 
ProteomicsHypoxia-induced proteomic remodeling of human mammary cancer associated fibroblast - siRNA NCBP2-AS2
Intratumoral hypoxia causes the formation of dysfunctional blood vessels which contribute to tumor metastasis. Blood vessels are embedded in the tumor stroma where cancer-associated fibroblasts (CAFs) constitute the most prominent cellular component. We found that hypoxic human mammary CAFs promote ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD006539 | Pride
Cancer Angiogenesis Hypoxia Silac Caf Proteome Secretome 
Sort   by:  
 Page size