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ProteomicsStructure of a Gcn2 dimer in complex with the large 60S ribosomal subunit
The integrated stress response (ISR) is a central signalling network that enables eukaryotic cells to respond to a variety of different environmental stresses. Such stresses cause ribosome collisions that lead to activation of the kinase Gcn2, resulting in the phosphorylation and inactivation of euk...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-09-16 | PXD055898 | Pride
Ribosome Cryoem 
ProteomicsThe S4-domain containing protein YlmH is involved in ribosome-associated quality control in Bacillus subtilis
By taking advantage of the strong genetic interactions between trans-translation and other ribosome rescue systems, we have employed a transposon sequencing (Tn-Seq) to identify potential novel rescue factors in Bacillus subtilis. In addition to the identification the ArfA-type rescue factor BrfA, a...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2024-09-16 | PXD049370 | Pride
Ylmh Translation Quality control 
TranscriptomicsDifferential RNA-seq for identifying toxin MazF and MqsR cleavage sites, beginning of transcripts and stationary phase cleavage sites in Escherichia coli (mRNA, rRNA and other ncRNA)
Bacterial toxin-antitoxin systems help bacteria to reduce their metabolism in various stressful conditions and also play a part in generating antibiotic tolerant bacterial subpopulation called persisters. Many toxins of the bacterial toxin-antitoxin systems are ribonucleases. Such toxins have been m...
ORGANISM(S): Escherichia coli K-12 
2016-11-30 | E-MTAB-4204 | biostudies-arrayexpress
OtherBovine sperm plasma membrane proteomics through biotinylation and subcellular enrichment.
Data from ProteomeXchange, PXD ID: PXD001096. File: 130508_01_Orbi1_SK_SER_G150_T158_BOSS_2xenrich_repl1_try.mzml. Published as part of Proteomics. 2015 Jan 20 . From the Abstract: {{i}} A significant proportion of mammalian fertilization is mediated through the proteomic composition of the sperm s...
ORGANISM(S): Cow 
GPM32320014064 | GPMDB
Resource Reanalysis 
TranscriptomicsThe general mode of translation inhibition by macrolide antibiotics
Macrolides are clinically important antibiotics thought to inhibit bacterial growth by impeding the passage of newly synthesized polypeptides through the nascent peptide exit tunnel of the bacterial ribosome. Recent data challenged this view by showing that macrolide antibiotics can differentially a...
ORGANISM(S): Escherichia coli BW25113 
2014-11-03 | E-GEOD-61619 | biostudies-arrayexpress
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