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GenomicsTENT5C Bcells
B cell humoral response and differentiation is regulated by non-canonical poly(A) polymerase TENT5C.
PRJEB33089 | ENA
ProteomicsEfficient globin production during terminal erythropoiesis depends on the cooperative action of TENT5C poly(A) polymerase and LARP4B in mice
To identify erythroid-specific TENT5C interactors, we employed a modified TurboID proximity biotinylation assay followed by MS/MS analysis of fetal liver erythroblasts differentiated ex vivo. We took advantage of Tent5c-EGFP knock-in mouse line and employed lentiviral vector expressing nanobody anti...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD072661 | Pride
Cytoplasmic polyadenylation Tent5c Erythropoiesis Interactome 
UnknownTENT5C functions as a corepressor in the ligand-bound glucocorticoid receptor and estrogen receptor α complexes.
Not available
S-EPMC12215964 | biostudies-literature
GenomicsB cell humoral response and differentiation is regulated by non-canonical poly(A) polymerase TENT5C.
B cell humoral response and differentiation is regulated by non-canonical poly(A) polymerase TENT5C.
PRJNA549395 | ENA
UnknownImmunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C.
Not available
S-EPMC7184606 | biostudies-literature
GenomicsEfficient globin production during terminal erythropoiesis depends on the synergistic action of TENT5C poly(A) polymerase and LARP4/5
Efficient globin production during terminal erythropoiesis depends on the synergistic action of TENT5C poly(A) polymerase and LARP4/5
PRJEB80123 | ENA
TranscriptomicsB cell humoral response and differentiation is regulated by non-canonical poly(A) polymerase TENT5C.
Purpose: The goal of this study was to assess changes in the activated B cells transcriptome upon TENT5C knockout in mice Methods: RNA-Seq data were obtained for LPS-activated primary B cells isolated from either wild-type or TENT5C KO mice Results: Immunoglobulins transcripts were found to be downr...
ORGANISM(S): Mus musculus 
2020-03-19 | GSE132883 | GEO
UnknownTENT5C extends <i>Odf1</i> poly(A) tail to sustain sperm morphogenesis and fertility.
Not available
S-EPMC11974682 | biostudies-literature
GenomicsSMARCA2 Deficiency Drives BTK Inhibitor Resistance in Mantle Cell Lymphoma by Metabolic Reprogramming via Epigenetic TENT5C Silencing
Mantle cell lymphoma (MCL) remains incurable, and resistance to Bruton's tyrosine kinase inhibitors (BTKis) limits long-term outcomes. Here, we identified SMARCA2 deletion or low expression as a driver of BTKi resistance and poor survival in MCL. SMARCA2 loss promoted proliferation and resistance by...
ORGANISM(S): Homo sapiens 
2026-09-23 | GSE326345 | GEO
TranscriptomicsSMARCA2 Deficiency Drives BTK Inhibitor Resistance in Mantle Cell Lymphoma by Metabolic Reprogramming via Epigenetic TENT5C Silencing [RNA-seq IGK]
Mantle cell lymphoma (MCL) remains incurable, and resistance to Bruton's tyrosine kinase inhibitors (BTKis) limits long-term outcomes. Here, we identified SMARCA2 deletion or low expression as a driver of BTKi resistance and poor survival in MCL. SMARCA2 loss promoted proliferation and resistance by...
ORGANISM(S): Homo sapiens 
2026-09-23 | GSE326343 | GEO
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