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ProteomicsProteomics of Mouse Testicular Organoids on Day 6
To investigate the mechanism for the formation of tubule-like structures in testicular organoids, we conducted proteomic analysis on O-Torgs and T-Torgs at day 6. Through differential protein expression and enrichment analysis, it was found that the extracellular matrix (ECM) related pathways in O-...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD075407 | Pride
Lc-msms Mouse Testicular organoids 
TranscriptomicsTranscription profiling of testis biopsies to investigate testis developmental gene expression in cryptorchid boys at risk of azoospermia
Despite timely and successful surgery, 32% of patients with bilateral and 10% with unilateral cryptorchidism will develop azoospermia. Cryptorchid boys at risk of azoospermia display a typical testicular histology of impaired mini-puberty at the time of the orchidopexy. During mini-puberty increased...
ORGANISM(S): Homo sapiens 
2010-11-23 | E-GEOD-25518 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis
Identification of gene expression patterns that correlate with distinct stages of male germ cell development using biopsies from men with highly defined and homogenous testicular pathologies based on the Johnsen score procedure. The Johnsen score procedure is a classical histopathological scoring pr...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-TABM-234 | biostudies-arrayexpress
TranscriptomicsKlinefelter Syndrome testicular gene expression profile by a whole genome microarray approach.
Objective: Klinefelter Syndrome (KS) is the most common sexual chromosome abnormality (47,XXY) and represents the first genetic cause of male infertility. The mechanisms leading to KS testis degeneration are still unclear and no therapy is so far available for affected patients. The present study is...
ORGANISM(S): Homo sapiens 
2014-06-15 | E-GEOD-54023 | biostudies-arrayexpress
TranscriptomicsTesticular gene expression profiles in infertile patients with AZFc deletions of the Y chromosome
In the present study we carried out testicular gene expression profiling of patients with AZFc microdeletion, idiopathic infertility and normal spermatogenesis, in order to identify up- and downregulated genes in the different conditions, and to verify the presence of specific molecular pathways le...
ORGANISM(S): Homo sapiens 
2010-10-04 | E-GEOD-14310 | biostudies-arrayexpress
TranscriptomicsThe gene expression analysis of paracrine/autocrine factors in patients with spermatogenetic failure compared to normal spermatogenesis
The role of paracrine/autocrine factors in inflammation, immune response and tumor development is well established. There is also an evidence that some of the cytokines there involved may participate in the regulation of the male gonads. However, their involvement in pathogenesis of male infertilit...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-45887 | biostudies-arrayexpress
UnknownRate of testicular histology failure in predicting successful testicular sperm extraction.
Not available
S-EPMC11499163 | biostudies-literature
TranscriptomicsPotential biomarkers tah could help to determine the prognosis of azoospermia treatment
We analyzed gene expression profiles of human testicular biopsies in men with idiopathic nonobstructive azoospermia who underwent therapy with hCG/rFSH. Using new generation oligonucleotide microarray platform GeneChip® Human Gene 1.0 ST, we identified genes which could be potential prognostic bio...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-51111 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of testicular biopsies with Sertoli-cell-only and spermatogonial presence
The aim of the study was to identify in vivo spermatogonial gene expression within the context of their biological niche. Identification of spermatogonial genes was done by t-testing on the replicates of Score 3 (Spermatogonia) and Score 2 (SCO) testicular biopsies. 3 biological replicates with sper...
ORGANISM(S): Homo sapiens 
2009-11-12 | E-GEOD-18997 | biostudies-arrayexpress
UnknownIn vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury.
Not available
S-EPMC9516847 | biostudies-literature
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