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MetabolomicsEmerging mechanisms and promising approaches in pancreatic cancer metabolism.

Pancreatic cancer is an aggressive cancer with a poor prognosis. Metabolic abnormalities are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to biosynthesis, energy intake and redox needs through metabolic reprogramming to tolerate nutrient deficiency and hypoxic ...

2025-03-26 | MTBLS12204 | MetaboLights
ProteomicsSperm-specific proteins and cancer testis antigens exist outside the blood-testis barrier
Sperm develop in the seminiferous tubules of the testis from puberty, sequestered inside the blood-testis barrier to prevent their recognition as “non-self” by the immune system. It is widely assumed that proteins expressed specifically in sperm do not have direct access to the circulation or the im...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-04-01 | PXD014333 | Pride
Testicular interstitial fluid Cancer-testis antigens Germ cell proteins 
ProteomicsIn-depth proteomic profiling of gastric cancer tumor cells uncovers previously unidentified cancer testis antigens
In-depth proteomic profiling of gastric cancer tumor cells uncovers previously unidentified cancer testis antigens
ORGANISM(S): Homo sapiens (Human) 
2024-06-06 | PXD047203 | Pride
[rptep Ocs 
ProteomicsSurpassing 10,000 identified and quantified proteins in a single run by optimizing current LC-MS instrumentation and data analysis strategy
Comprehensive proteome quantification is crucial for a better understanding of underlying mechanisms of diseases. Liquid chromatography mass spectrometry (LC-MS) has become the method of choice for comprehensive proteome quantification due to its power and versatility. Even though great advances hav...
ORGANISM(S): Homo sapiens (Human) 
2019-08-12 | PXD013658 | Pride
Liquid chromatography Dia Testis cancer Hybrid library 
GenomicsRRBS of human fetal testis treated to a mixture of DEHP/BPA
Fetal human fetal testes (8-11 weeks post-fertilization [WPF]) were cut into small pieces (~1 mm3 ) and 4-6 pieces/testis (depending of the age or size of the gonad) were insert into the muscle of the left back of two twin female mice. One week after surgery, one mouse was exposed by drinking water ...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-13840 | biostudies-arrayexpress
TranscriptomicsRNAseq of human fetal testis treated to a mixture of DEHP/BPA
Fetal human fetal testes (8-11 weeks post-fertilization [WPF]) were cut into small pieces (~1 mm3 ) and 4-6 pieces/testis (depending of the age or size of the gonad) were insert into the muscle of the left back of two twin female mice. One week after surgery, one mouse was exposed by drinking water ...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-13835 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human testis, primary myeloma cell and normal tissue samples to identify novel cancer-testis genes
Cancer-testis (CT) antigens are attractive targets for immunotherapeutic strategies since they are aberrantly expressed in malignant cells and not, or in limited number, in somatic tissues, except germ cells. To identify novel CT genes in multiple myeloma, we used Affymetrix HG-U133 gene expression ...
ORGANISM(S): Homo sapiens 
2009-01-20 | E-MTAB-81 | biostudies-arrayexpress
ProteomicsHuman testis phosphoproteome reveals kinases as potential targets in spermatogenesis and testicular cancer
Spermatogenesis is a complex cell differentiation process that includes marked genetic, cellular functional and structural changes. It requires tight regulation, since disturbances in any of the spermatogenic stages would lead to fertility deficiencies. In order to increase our knowledge of signal t...
ORGANISM(S): Homo sapiens (Human) 
2019-02-01 | PXD010246 | Pride
Human Testis Single-shot Phosphokinase ranking Label-free Phosphoproteomics 
GenomicsCancer/testis Antigen-Plac1 Promotes Invasion and Metastasis of Breast Cancer
Cancer/testis Antigen-Plac1 Promotes Invasion and Metastasis of Breast Cancer
PRJNA408149 | ENA
TranscriptomicsNext Generation Sequencing (RNAseq) of non-small cell lung cancer
Cancer testis antigens (CTAs) are of clinical interest as biomarkers and present valuable targets for immunotherapy. To comprehensively characterize the CTA landscape of non-small cell lung cancer (NSCLC), we compared RNAseq data of 199 NSCLC tissues to the normal transcriptome of 142 samples from 3...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-81089 | biostudies-arrayexpress
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