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TranscriptomicsGene expression profiling of human Th17 cell differentiation
The study aims at identifying transcriptional changes induced by in vitro polarization of human cord blood CD4+ cells towards Th17 subtype with combination of IL6, IL1b and TGFb by using timeseries data. In this study, we identified gene expression changes characterizing early stages of human Th17 c...
ORGANISM(S): Homo sapiens 
2012-05-03 | E-GEOD-35103 | biostudies-arrayexpress
TranscriptomicsComparative analysis of human and mouse transcriptomes of Th17 cell priming.
Uncontrolled Th17 cell activity is associated with cancer and autoimmune and inflammatory diseases. To validate the potential relevance of mouse models of targeting the Th17 pathway in human diseases we used RNA sequencing to compare the expression of coding and non-coding transcripts during the pri...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-GEOD-52260 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [IL1B_IL6_IL23-48h-IL-17A/GFP+]
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75109 | biostudies-arrayexpress
TranscriptomicsChemical Inhibition of the RORγt-dependent Transcriptional Network in Th17 cells [RNA-Seq 2]
RORγt is a transcription factor required for T helper 17 (Th17) cell development. We identified three RORγt-specific inhibitors that suppress Th17 cell responses including Th17 cell-mediated autoimmune disease. We systemically characterized RORγt binding data in the presence and absence of drug with...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-56240 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [TGFB1_IL6-48h]
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75110 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of Th17 cells, differentiated in vitro for 48h [TGFB1_IL6-48h-IL-17A/GFP+]
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75111 | biostudies-arrayexpress
TranscriptomicsPopulation transcriptional profiling of in vitro polarized Th17 cells, either sorted for IL17A/GFP+ or unsorted
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75103 | biostudies-arrayexpress
TranscriptomicsPopulation transcriptional profiling of KO or WT cells,, differentiated in vitro for 48-96h towards Th17 cells
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...
ORGANISM(S): Mus musculus 
2015-11-20 | E-GEOD-75104 | biostudies-arrayexpress
ProteomicsHuman Th17 Cell differentiation
The early stages of human Th17 Cell differentiation were studied using label free proteomics to compare Th17 polarized CD4+ human T cells at 24 h and 72 h with activated cells (72 and 24 h) and Thp cells.
ORGANISM(S): Homo sapiens (Human) 
2019-01-28 | PXD008973 | Pride
Th0 Human Cord blood Th17 Lc-ms/ms 
TranscriptomicsRNA-seq of in vitro-generated murine T helper 17 cells
T helper (Th) 17 cells form a T cell subset which is crucial to maintain immunity against extracellular bacteria and fungi at epithelial barriers, but Th17 cells are also enriched at sites of inflammation in autoimmune disease. These sites are commonly characterised by adverse environmental conditio...
ORGANISM(S): Mus musculus 
2017-06-14 | E-MTAB-5692 | biostudies-arrayexpress
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