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TranscriptomicsThe molecular basis of analgesia in congenital insensitivity to pain associated with loss of Nav1.7 function
Loss of function mutations in the SCN9a gene encoding voltage-gated sodium channel Nav1.7 cause congenital insensitivity to pain (CIP) and anosmia in otherwise normal humans and mice, suggesting that this channel may be a good analgesic drug target. Surprisingly, potent selective antagonists of ...
ORGANISM(S): Mus musculus 
2014-09-13 | E-GEOD-61373 | biostudies-arrayexpress
ProteomicsMapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene targeted mice
The voltage-gated sodium channel NaV1.7 plays a critical role in pain pathways. As well as action potential propagation, NaV1.7 regulates neurotransmitter release, integrates depolarizing inputs over long periods and regulates transcription. In order to better understand these functions, we generate...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-15 | PXD005155 | Pride
Pain Epitope-tagged nav1.7 mouse Mice The voltage-gated sodium channel nav1.7 Nav1.7 complexes affinity-purification Lc-ms/ms 
UnknownPhosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity.
Not available
S-EPMC7948457 | biostudies-literature
UnknownVeratridine modifies the gating of human voltage-gated sodium channel Nav1.7.
Not available
S-EPMC6289357 | biostudies-literature
UnknownThe voltage-gated sodium channel Nav1.7 associated with endometrial cancer.
Not available
S-EPMC6775510 | biostudies-literature
UnknownNaV1.6 and NaV1.7 channels are major endogenous voltage-gated sodium channels in ND7/23 cells.
Not available
S-EPMC6697327 | biostudies-literature
UnknownNetwork topology of NaV1.7 mutations in sodium channel-related painful disorders.
Not available
S-EPMC5324268 | biostudies-literature
UnknownPotency-Enhancing Mutations of Gating Modifier Toxins for the Voltage-Gated Sodium Channel NaV1.7 Can Be Predicted Using Accurate Free-Energy Calculations.
Not available
S-EPMC8002187 | biostudies-literature
UnknownHuman voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.
Not available
S-EPMC2799199 | biostudies-literature
UnknownVoltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Not available
S-EPMC3718154 | biostudies-literature
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