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ProteomicsFunctional proteomics identifies acinus L as a direct insulin- and amino acid-dependent mTORC1 substrate
The serine/threonine kinase mammalian target of rapamycin (mTOR) governs growth, metabolism, and aging in response to insulin and amino acids (aa), and is often activated in metabolic disorders and cancer. Much is known about the regulatory signaling network around mTOR, but surprisingly few direct ...
ORGANISM(S): Homo sapiens (Human) 
2015-04-28 | PXD001244 | Pride
Ap-ms Lc-ms Interactomics Human Mtor 
ProteomicsFunctional proteomics identifies acinus L as a direct insulin- and amino acid-dependent mTORC1 substrate
The serine/threonine kinase mammalian target of rapamycin (mTOR) governs growth, metabolism, and aging in response to insulin and amino acids (aa), and is often activated in metabolic disorders and cancer. Much is known about the regulatory signaling network around mTOR, but surprisingly few direct ...
ORGANISM(S): Homo sapiens (Human) 
2015-04-28 | PXD001245 | Pride
Lc-ms Human Ms-based in vitro kinase assay Mtor 
ProteomicsFunctional proteomics identifies acinus L as a direct insulin- and amino acid-dependent mTORC1 substrate
The serine/threonine kinase mammalian target of rapamycin (mTOR) governs growth, metabolism, and aging in response to insulin and amino acids (aa), and is often activated in metabolic disorders and cancer. Much is known about the regulatory signaling network around mTOR, but surprisingly few direct ...
ORGANISM(S): Homo sapiens (Human) 
2015-04-28 | PXD001196 | Pride
Lc-ms Silac Phosphoproteomics Human Mtor 
ProteomicsA systems study reveals concurrent activation of AMPK and mTOR by amino acids
Amino acids (aa) are not only building blocks for proteins, but also signalling molecules, with the mammalian target of rapamycin complex 1 (mTORC1) acting as a key mediator. However, little is known about whether aa, independently of mTORC1, activate other kinases of the mTOR signalling network. To...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-12 | PXD003073 | Pride
System modelling Ampk Silac Mtor Phosphoproteomics 
ProteomicsValidation of known and novel AKT, S6K and RSK targets by targeted MS
Using the global SILAC and label-free phosphoproteomics experiments as a basis, an inclusion list for validation of known and novel AKT, RSK and S6K targets comprising the RxRxxp[ST] motif was generated. Samples were analyzed by PRM-MS.
ORGANISM(S): Mus Musculus 
2023-02-27 | PXD035962 | panorama
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