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ProteomicsMass spectrometry analysis of the Themis1 interactome in murine thymocytes
Themis1, a recently described T-lineage specific protein, is essential for thymic positive and negative selection. Although Themis1 has been clearly identified as a component of the T cell antigen receptor (TCR) signalosome, its precise role in TCR signaling remains unclear. Here, we used quantitati...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-06 | PXD004072 | Pride
Thymocytes Ap-ms Tcr signalling Themis1 Interactome 
UnknownInterchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.
Not available
S-EPMC3401357 | biostudies-literature
UnknownProteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function.
Not available
S-EPMC5546195 | biostudies-literature
TranscriptomicsThemis1-mediated repression of SHP-1 activity promotes regulatory T cell suppressive functions through a Vav1-RelA signaling axis
Regulatory T cells (Tregs) expressing the transcription factor Foxp3 constitute a unique T cell lineage committed to suppressive functions and are crucial for suppressing aberrant immune responses in autoimmunity and allergy. Treg transcriptional landscape is tightly controlled by Foxp3-binding part...
ORGANISM(S): Mus musculus 
2021-06-01 | GSE165882 | GEO
GenomicsThemis1-mediated repression of SHP-1 activity promotes regulatory T cell suppressive functions through a Vav1-RelA signaling axis
Themis1-mediated repression of SHP-1 activity promotes regulatory T cell suppressive functions through a Vav1-RelA signaling axis
PRJNA698489 | ENA
UnknownThemis2 is not required for B cell development, activation, and antibody responses.
Not available
S-EPMC4082722 | biostudies-literature
ProteomicsHadBD dehydratase from Mycobacterium tuberculosis FAS-II: a singular structure for a unique function
Mycolic acids (MAs) are a unique class of lipids that are essential for viability, virulence and persistence of Mycobacterium tuberculosis (Mtb). Therefore, enzymes involved in MAs biosynthesis represent important class of drug targets. We previously showed that (3R)-hydroxyacyl-ACP dehydratase (HAD...
ORGANISM(S): Mycobacterium bovis BCG str. Pasteur 1173P2 
2024-03-21 | PXD043977 | Pride
(3r)-hydroxyacyl-acp dehydratase Structure-function relationships. Mycolic acids Hydratase 2 Mycobacterium tuberculosis Hotdog fold Crystal structure Catalytic subunit Substrate specificity Fatty acid synthase type ii system 
TranscriptomicsTranscriptional profiling of wildtype versus Themis2-deficient follicular B cells
This RNA-seqexperiment was designed to find transciptional differences between wildtype and Themis2-deficient B cells either directly ex-vivo or stimulated for 6 h with various stimuli in vitro. It is part of a larger study on the function of Themis2 in B cells. Therefore splenic, live, B220+ CD93- ...
ORGANISM(S): Mus musculus 
2014-06-10 | E-MTAB-2499 | biostudies-arrayexpress
UnknownThemis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.
Not available
S-EPMC2903609 | biostudies-literature
ProteomicsComparative proteomic analysis of mouse CD4+Foxp3+ regulatory T cells and CD4+Foxp3- conventional T cells
In this study, we compared the proteomes of mouse CD4+Foxp3+ regulatory T cells (Treg) and CD4+Foxp3- conventional T cells (Tconv) in order to build a data set of proteins differentially regulated in these two cell populations. The data set contains mass spectrometry results from the analysis of 7 b...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-10 | PXD004436 | Pride
Mouse primary t cell Expression proteomics Label-free Foxp3 Regulatory t cells 
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