Sort   by:  
 Page size 
TranscriptomicsSCL and LMO1 reprogram thymocytes into self-renewing cells.
The SCL and LMO1 oncogenic transcription factors reprogram thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Here we report that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1. Gene expression profiles of thymocytes from S...
ORGANISM(S): Mus musculus 
2015-11-05 | E-GEOD-74659 | biostudies-arrayexpress
ProteomicsMass spectrometry analysis of the Themis1 interactome in murine thymocytes
Themis1, a recently described T-lineage specific protein, is essential for thymic positive and negative selection. Although Themis1 has been clearly identified as a component of the T cell antigen receptor (TCR) signalosome, its precise role in TCR signaling remains unclear. Here, we used quantitati...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-06 | PXD004072 | Pride
Thymocytes Ap-ms Tcr signalling Themis1 Interactome 
TranscriptomicsTranscription profiling of mouse double negative thymocytes
In order to understand the molecular mechanisms of DN thymocyte development, it may be also of use to clarify how these developmental processes are regulated in terms of their entire gene expression, to which cell differentiation is ultimately ascribed. In the current study, we approached this iss...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7784 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse double-positive (CD4+CD8+) thymocytes following dexamethasone treatmen
Glucocorticoids play a role in regulation of T lymphocytes homeostasis and development. In particular, glucocorticoid treatment induces massive apoptosis of CD4+CD8+ double positive (DP) thymocytes. This effect is due to many mechanisms, mainly driven by modulation of gene transcription. To find out...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5463 | biostudies-arrayexpress
TranscriptomicsEffect of c-Myb deficiency on pre-selection DP thymocytes
Comparing the mRNA expression profiles of c-Myb deficient and c-Myb sufficient Tcra-/- DP thymocytes. Results provide insight into the role of c-Myb in the regulation of survival and differentiation during the pre-selection DP stage where c-Myb expression is abundant during T cell development. DP th...
ORGANISM(S): Mus musculus 
2010-01-21 | E-GEOD-19528 | biostudies-arrayexpress
ProteomicsAnalysis of CD5 signalosome in primary T cells
CD5 is characterized as an inhibitory co-receptor with important regulatory role during T cell development. To study the molecular mechanism by which CD5 operates, we used quantitative mass spectrometry to analyze the components of the CD5 signaling machinery in primary T cells. In a first set of ex...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-18 | PXD017343 | Pride
Tyrosine phosphorylation Cd5 Interactomics Tcr 
TranscriptomicsTranscriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression
The decline in adaptive immunity, naïve T-cell output and a contraction in the peripheral T cell receptor (TCR) repertoire with age are largely attributable to thymic involution and the loss of critical cytokines and hormones within the thymic microenvironment. To assess the molecular changes associ...
ORGANISM(S): Mus musculus 
2009-05-05 | E-GEOD-15945 | biostudies-arrayexpress
GenomicsRNA-seq of whole thymocytes and purified CD4+CD8+TCRlow DP thymocytes
RNA-seq of whole thymocytes and purified CD4+CD8+TCRlow DP thymocytes
PRJNA1268901 | ENA
TranscriptomicsDifferential Gene Expression in HDAC7-Deficient and Transgenic Thymocytes
Title of Publication: Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in CD4/CD8 Double-Positive Thymocytes Abstract of publicaton: CD4/CD8 double-positive (DP) thymocytes express the transcriptional repressor Histone Deacetylase 7 (HDAC7), a class IIa HDAC that is exported from the ...
ORGANISM(S): Mus musculus 
2011-04-06 | E-GEOD-26488 | biostudies-arrayexpress
Genomicsmurine DP thymocytes transcriptome
murine DP thymocytes transcriptome
PRJNA804863 | ENA
Sort   by:  
 Page size