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TranscriptomicsExpression data from mouse colon dendritic cell subsets
Characterization of colon CD11chigh/MHCII+ myeloid cell subsets Colon lamina propria MHC+CD11chigh cells were sorted on the basis of CD103 and CD11b expression as follows: CD103+CD11b-, CD103+CD11b+, CD103-CD11b+.
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-58446 | biostudies-arrayexpress
TranscriptomicsSynergism between curdlan and GM-CSF in mouse dendritic cells
A simultaneous engagement of different pathogen recognition receptors provides a tailor made adaptive immunity for an efficient defence against distinct pathogens. For example, cross talk of TLR and c-type lectin signalling effectively shapes distinct gene expression patterns by integrating the sign...
ORGANISM(S): Mus musculus 
2011-10-14 | E-GEOD-32986 | biostudies-arrayexpress
UnknownAdjustment of the PIF7-HFR1 transcriptional module activity controls plant shade adaptation
Not available
S-SCDT-EMBOJ-2019-104273 | biostudies-other
ProteomicsIn vivo proteolytic profiling of the type I and type II metacaspases in Chlamydomonas reinhardtii exposed to salt stress
Metacaspases are cysteine proteases present in plants, fungi and protists. While the association of metacaspases with cell death is studied in a range of organisms, their native substrates are largely unknown. Here, we explored the in vivo proteolytic landscape of the two metacaspases, CrMCA-I and C...
ORGANISM(S): Chlamydomonas reinhardtii 
2024-06-11 | PXD051835 | Pride
Lc-msms Chlamydomonas reinhardtii Metacaspase N-terminal enrichment 
TranscriptomicsTranscription profiling of Legionella pneumophila wild type vs rpoN mutant at OD 3.3
Comparison between Lp Paris wt and rpoN mutant in exponential phase (OD 3.3). We investigated the role of FleQ, FleR, RpoN, and FliA on the regulation of the expression of transmissive traits in L. pneumophila strain Paris at different time points (replicative phase, early transmissive phase, late t...
ORGANISM(S): Legionella pneumophila 
2009-12-02 | E-MTAB-175 | biostudies-arrayexpress
TranscriptomicsCodY in Staphylococcus aureus: regulatory link between metabolism and virulence gene expression
CodY is a conserved regulator in gram-positive organisms described to repress metabolic genes mainly involved in nitrogen metabolism but also to control the expression of virulence genes in pathogens. We constructed codY gene-replacement mutants in three unrelated S. aureus strains (Newman, UAMS-1, ...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2008-11-06 | E-GEOD-12340 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of CD4+ T cells in experimental autoimmune encephalitomyelitis
In this study we determined whole genome gene expression of murine naive CD4+ T cells, in vitro differentiated Th17 cells, and CD4+ T cells isolated from experimental autoimmune encephalitomyelitis (EAE)-affected animals either after adoptive transfer of Th17 cells or after immunization with MOG35-5...
ORGANISM(S): Mus musculus 
2015-02-26 | E-GEOD-57098 | biostudies-arrayexpress
ProteomicsThe proteolytically inactive orthocaspase of Synechocystis sp. PCC 6803 plays an important role during oxidative stress
Caspases are proteases, best known for their involvement in the execution of apoptosis – a subtype of programmed cell death, which occurs only in animals. These proteases are composed of two structural building blocks: a proteolytically active p20 domain and a regulatory p10 domain. Although structu...
ORGANISM(S): Synechocystis sp. PCC 6803 
2021-09-09 | PXD022955 | Pride
Programmed cell death Orthocaspases Stress Metacaspases Pseudo-enzymes Cyanobacteria. 
TranscriptomicsGene expression profiling of antigen-specific T cells upon CCR9 knockdown in MCF7 cells.
Tumor cells are known to express immune-inhibitory ligands on their surface to mediate resistance against cytotoxic T lymphocytes. Using a high-throughput RNAi screening assay, we identified CCR9 as a potent tumor-specific immune checkpoint molecule that inhibited T cell-mediated tumor lysis. To und...
ORGANISM(S): Homo sapiens 
2015-02-19 | E-MTAB-3244 | biostudies-arrayexpress
TranscriptomicsThe stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression
The stringent response is initiated by rapid (p)ppGpp synthesis, which leads to a profound reprogramming of gene expression in most bacteria. The stringent phenotype seems to be species specific and may be mediated by fundamentally different molecular mechanisms. In Staphylococcus aureus, (p)ppGpp s...
ORGANISM(S): Staphylococcus aureus 
2013-04-05 | E-GEOD-45617 | biostudies-arrayexpress
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