Sort   by:  
 Page size 
ProteomicsProteogenomics analysis unveils a novel TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
Papillary thyroid cancer (PTC) is the most common type of endocrine malignancy. From a set of PTC patients whose tumor did not harbour any BRAF or RAS mutations, a 35 years old male patient’s normal, primary tumor and lymph node (LN) metastatic tissues were subjected to genomics and proteomics analy...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD016828 | Pride
Ptc/ ret/ huwe1/ usp7/ usp9x / precision medicine/ tfg-ret 
ProteomicsLarge scale intact glycopeptide identification by Mascot database search
We present the adaptability of Mascot search engine for automated identification of intact glycopeptide mass spectra. The steps involved in adopting Mascot for intact glycopeptide analysis include: i) assigning unique one letter codes for monosaccharides, ii) linearizing glycan sequences and iii) pr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-02 | MSV000082567 | MassIVE
TranscriptomicsGene expression profiling in AML with normal karyotype: A multicenter study investigating molecular markers in 251 cases
Acute myeloid leukemia (AML) is a heterogeneous disease and AML with normal karyotype (AML-NK) is categorized as an intermediate-risk group. Over the past years molecular analyses successfully identified biomarkers that will further allow to dissecting clinically meaningful subgroups in this disease...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-15434 | biostudies-arrayexpress
TranscriptomicsExpression changes in Caenorhabditis elegans xpa-1 mutant
Background: The ability of an organism to repair DNA damage is implicated in carcinogenesis and aging. Interestingly expression profiling of Nucleotide Excision Repair (NER) deficient segmental progeroid mice revealed gene expression changes resembling these observed in aged wild type animals. Our p...
ORGANISM(S): Caenorhabditis elegans 
2013-05-03 | E-GEOD-39252 | biostudies-arrayexpress
ProteomicsComparison of LFQ and IPTL for protein identification and relative quantification
Mass spectrometry-based quantitative proteome profiling is most commonly performed by label-free quantification (LFQ), stable isotopic labeling with amino acids in cell culture (SILAC), and reporter-ion based isobaric labeling methods (TMT and iTRAQ). Isobaric peptide termini labeling (IPTL) was des...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026942 | Pride
Tmt Silac Lfq Quantitative proteomics Iptl 
ProteomicsHalf decimal place rule
Many MS2 spectra in bottom-up proteomics experiments remain unassigned. To improve proteome coverage, we applied the half decimal place rule (HDPR) to remove non-peptidic molecules. The HDPR considers the ratio of the first digit after the decimal point to the full molecular mass and results in a re...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080727 | MassIVE
TranscriptomicsTranscription profiling of human mesenchymal stem cell derived stromal and adipocyte cells treated with insulin.
There are an estimated 21million diabetics in the United States and 150 million diabetics worldwide. The World Health Organization anticipates that these numbers will double in the next 20 years. Metabolic syndrome is a well recognized set of symptoms that increases a patient’s risk of developing d...
ORGANISM(S): Homo sapiens 
2010-11-30 | E-GEOD-24422 | biostudies-arrayexpress
ProteomicsA regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in breast cancer survival
Cytosine deamination to uracil in DNA leads to mutations if the DNA lesion is not corrected. Base excision repair (BER) initiated by single-strand selective uracil-DNA glycosylase 1 (SMUG1) primarily recognizes uracil and oxidized pyrimidines, and processes them to restore the correct bases. SMUG1 s...
ORGANISM(S): Homo sapiens (Human) 
2023-03-09 | PXD025929 | Pride
Smug1 Breast cancer Dna repair Rna and ribonucleoprotein biogenesis Hsa-let-7b-5p Modified bases 
UnknownLong-Time-Scale Predictions from Short-Trajectory Data: A Benchmark Analysis of the Trp-Cage Miniprotein.
Not available
S-EPMC8903024 | biostudies-literature
UnknownMarriage, Work, and Racial Inequalities in Poverty: Evidence from the U.S.
Not available
S-EPMC5667656 | biostudies-literature
Sort   by:  
 Page size