Sort   by:  
 Page size 
MetabolomicsThioridazine induce phospholipid accumulation and necroptosis in breast cancer cells
An antipsychotic drug, Thioridazine has been shown to inhibit a broad spectrum of cancer cells. However, its molecular mechanism is still not well understood. In the present study, we have shown that thioridazine induces cytostatic effects in both parental and tamoxifen-resistant cancer cells throug...
2025-02-20 | MTBLS11870 | MetaboLights
TranscriptomicsResponse of methicillin-resistant Staphylococcus aureus USA300 to a subinhibitory concentration of thioridazine - alone and in combination with dicloxacillin
Subinhibitory concentrations of the neuroleptic drug thioridazine (TDZ) are well-known to enhance the killing of methicillin-resistant S. aureus (MRSA) by β-lactam antibiotics, however, the mechanism underlying the synergy between TDZ and β-lactams is not fully understood. In the present study we ...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300_FPR3757 
2013-05-20 | E-GEOD-43759 | biostudies-arrayexpress
TranscriptomicsGlobal modulation of gene expression in Paracoccidioides brasiliensis in response to thioridazine
Phenothiazines are antipsychotic drugs used in the treatment of schizophrenia, which have been shown to present antimicrobial activity (in vitro and in vivo) against a great variety of pathogenic microorganisms, including bacteria, parasites (protozoa and helmints) and fungi. In this study, we used ...
ORGANISM(S): Paracoccidioides brasiliensis 
2013-12-31 | E-GEOD-41881 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse frontal cortex after treatment with zntipsychotic drugs
Antipsychotic drugs are classified as typical and atypical based on extrapyramidal effects. However, since the frontal cortex is one of the most important regions for antipsychotic actions, this study attempted to classify antipsychotic drugs based on gene expression in the frontal cortex. Chlorprom...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-1501 | biostudies-arrayexpress
ProteomicsExposure of Mycobacterium tuberculosis to thioridazine alters the cell envelope permeability; an alternative mechanism for the synergistic effects with other antibiotics
The emergence of multidrug resistant tuberculosis and the increasing level of resistance urges the search for alternative drugs in treatment. Several neuroleptics, like thioridazine, reveal activity against Mycobacterium tuberculosis. Thioridazine was even successfully applied in compassionate thera...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2016-07-06 | PXD001208 | Pride
Proteomics Mycobacterium tuberculosis Thioridazine Lc-ms/ms 
GenomicsThioridazine induces pyrolysis and autophagy in epithelial ovarian cancer
Thioridazine induces pyrolysis and autophagy in epithelial ovarian cancer
PRJNA1255197 | ENA
TranscriptomicsThioridazine induces pyrolysis and autophagy in epithelial ovarian cancer
Thioridazine exhibits inhibitory effects on various tumors, including epithelial ovarian cancer, but the mechanisms remain unclear. Proliferation and invasion were assessed using CCK8 and Matrigel invasion assays. Autophagy and pyroptosis-related markers were detected via Western blot. Autophagy flu...
ORGANISM(S): Homo sapiens 
2025-04-24 | GSE295565 | GEO
UnknownMolecular mechanisms of thioridazine resistance in Staphylococcus aureus.
Not available
S-EPMC6082566 | biostudies-literature
UnknownThioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation.
Not available
S-EPMC10545737 | biostudies-literature
GenomicsDifferential gene expression analysis between pre-metamorphic WT control X. laevis tadpoles and tadpoles with thioridazine-induced craniofacial abnormalities.
Differential gene expression analysis between pre-metamorphic WT control X. laevis tadpoles and tadpoles with thioridazine-induced craniofacial abnormalities.
PRJNA528872 | ENA
Sort   by:  
 Page size