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TranscriptomicsTargets of the transcription factor Brachyury in differentiating mouse ES cells
Brachyury (or T) is expressed in the primitive streak, tailbud and notochord of the early mouse embryo (Herrmann et al., 1990; Wilkinson et al., 1990). It plays a key role in early development: mouse embryos lacking functional Brachyury protein fail to gastrulate properly, do not form a differentiat...
ORGANISM(S): Mus musculus 
2012-05-28 | E-GEOD-16646 | biostudies-arrayexpress
ProteomicsTotal synthesis of rosette inhibitor IOR allows its functional analysis and evaluation of sulfonolipid-based chemical probes
The predatory choanoflagellate Salpingoeca rosetta has emerged as important model systems to study the evolution of multicellularity and chemical origin of bacterial-eukaryote communication mechanisms. In this study we elaborated on the function and possible proteogenic binding partners of the bacte...
ORGANISM(S): Algoriphagus machipongonensis Echinicola pacifica Salpingoeca rosetta 
2022-08-29 | PXD034064 | Pride
Salpingoeca rosetta Photoaffinity-labeling Sulfonosphingolipids Choanoflagellate Lc-ms/ms 
ProteomicsCreA phosphorylation sites are important for the regulation of carbon catabolite repression in filamentous fungi
Saprobic microorganisms, such as filamentous fungi of the genus Aspergillus, are of particular interest for biotechnological applications due to their natural capacity to secrete plant cell wall-degrading enzymes that are known as carbohydrate-active enzymes (CAZy). The presence of easily metaboliza...
ORGANISM(S): Emericella nidulans (Aspergillus nidulans) 
2021-02-18 | PXD018967 | Pride
Lc-ms Aspergillus nidulans Crea Carbon catabolite repression Phosphoproteomics 
ProteomicsFunctional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target
More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus. The azole class of antifungals represent first line therapeutics for most of these infections however resistance is rising. Identification of novel antifungal targets that, when inhibited, sy...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2024-04-09 | PXD042616 | Pride
Mass spectrometry Aspergillus fumigatus Phosphoproteomics Antifungal drug target Kinome 
TranscriptomicsGene expression profile of mouse breast cancer V720 cells treated with vehicle or PD 0332991
D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains which allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D associated...
ORGANISM(S): Mus musculus 
2012-10-16 | E-GEOD-40513 | biostudies-arrayexpress
GenomicsLoss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis
Multiple endocrine neoplasia type 1 (MEN1) syndrome is the result of mutations in the MEN1 gene and results in tumor formation via mechanisms that are not well understood. Using a novel genome-wide methylation analysis, we studied tissues from patients with MEN1-parathyroid tumors, tissues from Men1...
ORGANISM(S): Homo sapiens 
2015-12-22 | E-GEOD-64412 | biostudies-arrayexpress
ProteomicsTime-Dependent Proteome Study: Human ovarian cancer tumor samples (0, 5, 30, 60 min)

The objective of the Time-Dependent Proteome Study, was to evaluate changes in the proteome and phosphoproteome when there is a delay in freezing tissues following sample (tumor) excision. The biospecimens used are from patient-derived ovarian cancer tumors.

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-11-05 | MSV000083107 | MassIVE
GenomicsUQ Data Access Commitee
Data Access Committee EGAC00001002686
EGAC00001002686 | EGA
ProteomicsIschemiaOC_Proteome_PNNL
Human Ovarian Cancer, iTRAQ
ORGANISM(S): Homo Sapiens (human) 
2014-12-31 | PAe004951 | PeptideAtlas
Genomicsb1db14cd-994c-4440-908e-9e7aab02d88f - samples
This dataset contains one vcf file with variants from whole exome sequencing of 24 paediatric AML samples at diagnosis.
EGAD00001008783 | EGA
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