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TranscriptomicsTranscription profiling of human endothelial progenitor cells (EPC) vs. human umbilical vein endothelial cells (HUVEC) vs. CD14+ monocytes
Comparison of mRNA expression in human EPC vs. HUVEC vs. human monocytes. Cell-type specific gene expression under basal cell culture conditions (no stimulation). The hybridization was performed with three samples of EPC vs. three samples of HUVEC vs. 3 samples of CD14+ monocytes. â?¢ The origin of ...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-2040 | biostudies-arrayexpress
TranscriptomicsTime Course Gene Expression Microarray Analysis of a Mouse B-cell Line (CH12.LX) Activated with Lipopolysaccharide and Treated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin
The objective of the study was to characterize gene expression cascade involved in the suppression of B-cell activation and differentiation by 2,3,7,8-tetrachlorodibenzo-p-dixoxin (TCDD). The underlying hypothesis was that multiple nodes in the B-cell differentiation network are directly or indirect...
ORGANISM(S): Mus musculus 
2010-10-21 | E-GEOD-21272 | biostudies-arrayexpress
TranscriptomicsChromatin Immunoprecipitation Analysis of Aryl Hydrocarbon Receptor Binding in a Mouse B-cell Line (CH12.LX) Activated with Lipopolysaccharide and Treated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin
The aryl hydrocarbon receptor (AHR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters differentiation of B cells and suppresses antibody production. The objectives of this study was to use a combination of whole genome, microarray-based chromatin immunoprecipitation (ChIP-on-chip) and time ...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23708 | biostudies-arrayexpress
TranscriptomicsBasal Gene Expression Measurements in HEK293T Cells
Gene expression microarray profile for human embryonic kidney cells (HEK293T, CRL-11268) under untreated conditions. Gene expression microarray profile for human embryonic kidney cells (HEK293T, CRL-11268) under untreated conditions (DMEM, 10% FBS).
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-21092 | biostudies-arrayexpress
TranscriptomicsSuv39h-dependent H3K9me3 represses intact retrotransposons in mouse embryonic stem cells
Heterochromatin is required to restrict aberrant expression of retrotransposons, but it remains poorly defined due to the underlying repeat-rich sequences. We dissected Suv39h-dependent histone H3 lysine 9 trimethylation (H3K9me3) by genome-wide ChIP-sequencing in mouse embryonic stem cells (ESCs). ...
ORGANISM(S): Mus musculus 
2014-06-26 | E-GEOD-57092 | biostudies-arrayexpress
TranscriptomicsAbrogation of stromal TGF-β signaling induces genetic alterations and SCC development in the neighboring epithelia
Specific deletion of Tgfbr2 in FSP1+ fibroblasts (Tgfbr2fspKO) induced development of SCC in forestomach with 100% penetrance. Tgfbr2fspKO mice die by 7 weeks with a median survival of 38 days (Log rank p<0.001). Examination of Tgfbr2fspKO forestomach between embryonic day 16 (E16) and 5 weeks of ag...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-42773 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling in human T-ALL
Genome-wide mapping and characterization of novel Notch-regulated long non-coding RNAs in acute leukemia Total RNA was extracted from samples using the RNeasy Plus mini kit (Life Technologies, Carlsbad, CA). Samples were then subject to PolyA selection (Figures 1E, 5F and 5G only) using oligo-dT be...
ORGANISM(S): Homo sapiens 
2014-08-18 | E-GEOD-57982 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq from human prostate cancer-adjacent benign prostatic hyperplasia
Determine a comprehensive transcriptome sequencing profiling of tumor-adjacent (contralateral lobe) benign prostatic hyperplasia, 10X genomics single-cell RNA-sequencing analysis on human surgical specimen.
ORGANISM(S): Homo sapiens 
2025-12-16 | E-MTAB-13764 | biostudies-arrayexpress
TranscriptomicsC/EBPα induces highly efficient macrophage transdifferentiation of selected B-lymphoma /leukemia cell lines and impairs their tumorigenicity
Earlier work demonstrated that the transcription factor C/EBPα can convert immature and mature murine B lineage cells into functional macrophages. Testing >20 human lymphoma and leukemia B-cell lines, we found that most can be transdifferentiated at least partially into macrophage-like cells, provi...
ORGANISM(S): Homo sapiens 
2013-03-14 | E-GEOD-44700 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse B16-F10 melanoma cells transfected with FoxD3
We wished to examine the genes regulated by FoxD3 in pigment cells to gain understanding in how FoxD3 represses melanoblast specification in the neural crest. For technical reasons, we could not use neural crest cells, so we used melanoma cells, since they are derived from neural crest cells. To t...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-13129 | biostudies-arrayexpress
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