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ModelsOstreococcus tauri forced clock - code-faithful unnormalised parameterization
This model describes light entrainment of the Ostreococcus tauri circadian clock through a minimal network combining the TOC1–CCA1 core oscillator with the putative photoreceptors LOV-HK and Rhod-HK. The model contains ten ordinary differential equations describing mRNA and protein dynamics for CCA1...
2026-09-02 | MODEL2608180002 | BioModels
ModelsThommen2010 - Robustness of Circadian Clocks to Daylight Fluctuations: Hints from the Picoeucaryote Ostreococcus tauri
This model describes the free-running circadian oscillator of *Ostreococcus tauri* proposed by Thommen et al. (2010). It consists of a minimal transcriptional feedback loop involving the clock genes **TOC1** and **CCA1**, represented by four ordinary differential equations for their mRNA and protein...
2026-09-02 | MODEL2608180001 | BioModels
ModelsSivery2016 - A mammalian heat shock response model
Environmental stress, such as oxidative or heat stress, induces the activation of the heat shock response (HSR) and leads to an increase in the heat shock proteins (HSPs) level. These HSPs act as molecular chaperones to maintain cellular proteostasis. Controlled by highly intricate regulatory mechan...
2022-01-25 | MODEL2201210001 | BioModels
ModelsStress priming and thermotolerance model - Pfeuty et al. 2021
The model describes cellular adaptation to proteotoxic stress through four dynamical variables: protein damage, cell survival, molecular chaperone mRNA and molecular chaperone protein. Heat increases the production of misfolded proteins, which are either degraded or repaired by chaperones. Accumulat...
2026-09-02 | MODEL2608180005 | BioModels
ModelsHeat shock response network model from Guilbert et al. 2020
The model describes the mammalian heat shock response network using four dynamical variables: temperature, misfolded proteins (MFP), HSP mRNA, and heat shock proteins (HSP). Heat stress increases protein denaturation, generating MFPs that compete with HSF1 for binding to HSP chaperones. This sequest...
2026-09-02 | MODEL2608180003 | BioModels
ModelsMinimal dynamical thermal dose model - Ladjimi et al. 2019
The model provides a minimal mechanistic description of cellular survival under hyperthermia. Heat induces the production of misfolded proteins, which are either degraded or repaired by molecular chaperones. The repair process is saturable because chaperone resources are limited, causing misfolded p...
2026-09-02 | MODEL2608180004 | BioModels
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