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UnknownCombination therapy with sitagliptin and lansoprazole in patients with recent-onset type 1 diabetes (REPAIR-T1D): 12-month results of a multicentre, randomised, placebo-controlled, phase 2 trial.
Not available
S-EPMC4283272 | biostudies-literature
ProteomicsComprehensive respiratory phenomics across multiple models of mitochondrial protein hyperacylation reveals a paradoxically marginal impact on bioenergetics
Acyl CoA metabolites derived from catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translation modifications (PTMs). Mass spectrometry-based detection of thousands of acyl-PTMs scattered throughout the proteome has established...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-07 | PXD011375 | JPOST Repository
ProteomicsA class of reactive acyl-CoA species reveals the nonenzymatic origins of protein acylation
The mechanisms underlying the formation of acyl protein modifications remain poorly understood. By investigating the reactivity of endogenous acyl-CoA metabolites, we found a class of acyl-CoAs that undergoes intramolecular catalysis to form reactive intermediates which non-enzymatically modify prot...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-11 | PXD005895 | Pride
Glutarylation Hmgylation Nonenzymatic protein acylation 
ProteomicsSIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion
Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic activity of mitochondrial sirtuin 4 (SIRT4) and its overall role in metabolic control has remained enigmatic. Using a combination o...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-05 | PXD005896 | Pride
Protein acylation Insulin secretion Leucine metabolism Sirt4 
TranscriptomicsAT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress
UnknownThe benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial.
Not available
S-EPMC3386495 | biostudies-literature
UnknownThe importance of dominance and genotype-by-environment interactions on grain yield variation in a large-scale public cooperative maize experiment.
Not available
S-EPMC8022981 | biostudies-literature
UnknownTreatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.
Not available
S-EPMC7597675 | biostudies-literature
UnknownStructural basis for potency differences between GDF8 and GDF11.
Not available
S-EPMC5336696 | biostudies-literature
TranscriptomicsSubgroup specific somatic copy number aberrations in the medulloblastoma genome [gDNA]
Affymetrix SNP6 profiling of 1087 medulloblastoma samples and 10 medulloblastoma cell lines. Genomic DNA was extracted from primary medulloblastoma samples and medulloblastoma cell lines and hybridized to Affymetrix SNP6 arrays according to the manufacturer's instructions.
ORGANISM(S): Homo sapiens 
2012-07-26 | E-GEOD-37384 | biostudies-arrayexpress
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