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ProteomicsCaffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells
Caffeine is a well-known purine alkaloid commonly found in coffee. Several lines of previous and recent evidence have shown that habitual coffee drinking is associated with lower risks for chronic kidney disease (CKD) and nephrolithiasis. However, cellular and molecular mechanisms underlying its ren...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2023-12-11 | PXD045313 | Pride
Ckd  coffee  energy  kidney  metabolism  nephrolithiasis  proteomics  renoprotection 
ProteomicsDeciphering the impact of ectopic SNAI1 expression on renal tubular cell proteome and functions
Snail1 is crucial in regulating epithelial mesenchymal transition (EMT), which leads to excessive extracellular matrix (ECM) production and organ fibrosis including the kidney. Elucidating the roles of snail1 in EMT and kidney fibrosis is thus vital for developing targeted therapies. This study inve...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD061033 | Pride
Renal fibrosis Senescence Proteomics Snail1 Kidney 
ProteomicsCharacterizations of HSP90-interacting complex in renal cells using tandem affinity purification and its potential role in kidney stone formation
Heat shock protein 90 (HSP90) is a highly abundant molecular chaperone that interacts with many other intracellular proteins to regulate various cellular processes. However, compositions of the HSP90-interacting complex remain underinvestigated. This study thus aimed to characterize such complex in ...
ORGANISM(S): Homo sapiens (Human) 
2018-12-17 | PXD011432 | Pride
Chaperone  heat shock protein 90  hek293t  kidney stone  sirna  tap tag 
ProteomicsEffects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation
The association between kidney stone disease and renal fibrosis has been widely explored in recent years but its underlying mechanisms remain far from complete understanding. Using label-free quantitative proteomics (nanoLC-ESI-LTQ-Orbitrap MS/MS), this study identified 23 significantly altered secr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD027039 | Pride
Calcium oxalate  kidney stone  macrophage  renal fibrosis  secretome 
ProteomicsOxidative modifications of urinary proteins increase kidney stone risk
Clinical and animal studies have demonstrated the increasing evidence of oxidative stress in kidney stone disease. Recent findings have shown that the interactions between calcium oxalate (CaOx) crystals and renal tubular cells can promote many cellular events such as cell proliferation, cell death,...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD019360 | Pride
Calcium oxalate  kidney stone  oxidative stress  post-translation modification  uromodulin 
ProteomicsProtective cellular mechanism of estrogen against kidney stone formation: A proteomics approach and functional validation
Kidney stone disease is influenced by multiple factors, including but not limited to age, gender, genetic background, hydration status, diet and drug. Regarding the gender, epidemiologic data across the world has shown that females at the reproductive age (15-49 years) have lower incidence/prevalenc...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2019-09-09 | PXD014768 | Pride
Female Kidney stone Nephrolithiasis Gender  hormone Estradiol 
ProteomicsQuantitative proteomics reveals common and unique molecular mechanisms underlying beneficial effects of caffeine and trigonelline on human hepatocytes
Caffeine and trigonelline are the major bioactive compounds in coffee. Caffeine alone or combined with other coffee compounds shows hepatoprotective effects. However, molecular mechanisms underlying such hepatoprotective effects remain unclear. We therefore addressed molecular effects of caffeine an...
ORGANISM(S): Homo sapiens (Human) 
2023-12-05 | PXD037553 | Pride
Coffee  hepatoprotection  hepg2  protein synthesis  ribosome  translation 
ProteomicsProteomic and computational analyses followed by functional validation of protective effects of trigonelline against calcium oxalate-induced renal cell deteriorations
Trigonelline is a phytoalkaloid commonly found in green and roasted coffee beans. It is also found in decaffeinated coffee. Previous report has shown that trigonelline-rich plant extract exhibits anti-lithiatic effects in a nephrolithiatic rat model. Nevertheless, cellular mechanisms underlying the ...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2024-11-19 | PXD047028 | Pride
Anti-lithiatic  bioactive compound  bioinformatics  coffee  kidney stone  proteomics  reactome 
ProteomicsUrinary proteins from stone formers promote calcium oxalate crystallization, growth and aggregation via oxidative modifications
Various urinary parameters have been used to determine kidney stone risk. However, almost all of the widely used lithogenic indices rely on urinary concentrations of small molecules/ions and pH. We hypothesized that urinary macromolecules (especially proteins) also play a critical role in determinin...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD050609 | Pride
Nephrolithiasis  oxidized protein  risk factor  stone modulator  urinary protein  urolithiasis 
ProteomicsCharacterizations of HSP90-interacting complex in renal cells using tandem affinity purification and its potential role in kidney stone formation
Heat shock protein 90 (HSP90) is a highly abundant molecular chaperone that interacts with many other intracellular proteins to regulate various cellular processes. However, compositions of the HSP90-interacting complex remain underinvestigated. This study thus aimed to characterize such complex in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-12-17 | MSV000083252 | MassIVE
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