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TranscriptomicsDifferentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro infection of THP-1 human macrophage cell line
Transcriptional profile of Mycobacterium avium subspecies paratuberculosis in in vitro THP-1 (ATCC TIB-202) cell line infection, comparing bacteria grown in host medium and intracellular bacteria recovered from infected THP-1 cells. Two-condition experiment, MAP-K vs. intracellular MAP-THP-1. Biolog...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-05-31 | E-GEOD-32242 | biostudies-arrayexpress
MetabolomicsDynamic single-cell metabolomics reveals cell-cell interaction between tumor cells and macrophages

Single-cell metabolomics reveals cell heterogeneity and elucidates intracellular molecular mechanisms. However, general concentration measurement of metabolites can only provide a static delineation of metabolomics, lacking the metabolic activity information of biological pathways. Herein, we dev...

2025-04-14 | MTBLS11091 | MetaboLights
MetabolomicsSingle-cell time-resolved multi-omics reveal apoptotic and ferroptotic heterogeneity during foam cell formation

Macrophage-derived foam cell plays a pivotal role in the plaque formation and rupture during the progression of atherosclerosis. Foam cells are destined to divergent cell fate and functions in response to external stimuli based on their internal states, which however is hidden in the traditional ...

2023-09-08 | MTBLS6366 | MetaboLights
TranscriptomicsGlobal transcriptional response of macrophage-like THP-1 cells
Shiga toxins (Stxs) are bacterial cytotoxins produced by the enteric pathogens Shigella dysenteriae serotype 1 and some serotypes of Escherichia coli that cause bacillary dysentery and hemorrhagic colitis, respectively. To date, approaches to studying the capacity of Stxs to alter gene expression in...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19315 | biostudies-arrayexpress
ProteomicsNuclear and total proteins in THP-1 cell differentiation
THP-1 monocyte-like suspension cells can be differentiated into macrophage-like adherent cells by TPA (PMA) treatment. Proteomic analysis was carried out on (i) normal THP-1 cells, (ii) THP-1 cells in which KPNA1 (importin-alpha5) was knocked down or not by siRNA, and (iii) THP-1 TetOn-KPNA2 (import...
ORGANISM(S): Homo Sapiens (human) 
2025-02-15 | PXD049401 | JPOST Repository
TranscriptomicsGene expression profile of DAP12 knockdown THP-1 cells following exposure to phorbol 12-myristate 13-acetate
Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare autosomal recessive disorder characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-33503 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human actute monocytic leukemia cell line THP-1 cells incubated at 37 or 32 degrees C for 24h reveals moderate hypothermia produces substantial changes in cellular gene expression, in categories potentially of importance to systemic function.
Background: Moderate hypothermia (32oC for 12 – 72 hours) has therapeutic applications, but the mechanisms by which it affects cellular function are unclear. We tested the hypothesis that moderate hypothermia produces broad changes in gene expression by human cells at the level of mRNA. Methods:...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4425 | biostudies-arrayexpress
TranscriptomicsGene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease
Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare autosomal recessive disorder characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-33500 | biostudies-arrayexpress
TranscriptomicsCaco-2 cocultured with THP-1, time course
Previously, we constructed a coculture model to analyze the effect of macrophages on intestinal epithelial cells, and found that TNF-a secreted from human macrophage-like THP-1 cells induced cell damage to intestinal epithelial Caco-2 cells (Exp.Cell.Res. 2006, 312(19):3909-19). In this study, we pr...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-17625 | biostudies-arrayexpress
TranscriptomicsRNAseq of differentiation states of primary monocytes and THP-1 cells (from two depositors)
Intensive usage of cancer cell lines as cellular model system in cancer research caused the generation of variant subtypes during the last decades. This study focused on the human leukemic THP-1 cell line as a monocyte model. THP-1 cells from two different depositors were differentiated into variou...
ORGANISM(S): Homo sapiens 
2026-07-24 | E-MTAB-17225 | biostudies-arrayexpress
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